TCRg/d

The Anti-TCRγ/δ-1 antibody, clone 11F2, is a monoclonal antibody produced by hybridizing mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with a Sepharose® bead/CD3/γ/δ TCR complex. The γ/δ TCR is a heterodimeric glycoprotein that is noncovalently associated with the CD3 antigen 1 . The γ and δ TCR chains consist of constant and variable regions, each encoded by distinct gene segments 2 .
The γ chain can form either disulfide-linked or non-disulfide-linked heterodimers with the δ-subunit 3 . The γ/δ TCR is involved in the recognition of a diverse array of antigens and plays a critical role in the immune response. It is particularly important in the context of non-peptide antigens and stress-induced ligands 3 . This antibody is suitable for the detection and analysis of γ/δ TCR expression in various cell types using flow cytometry. It is particularly useful in research focused on T-cell development, immune response, and antigen recognition.