ThromboStep:
Diagnostic kit designed to quantify platelet associated immunoglobulin using Flow Cytometry
Immune Thrombocytopenia
Normal human platelet counts range from 150,000 to 450,000 platelets per microlitre of blood. Thrombocytopenia is the presence of too few platelets.
Decreased platelet counts may be due to different pathological processes, however, quantification of platelets associated with immunoglobulins allows the cause of thrombocytopenia to be related to a decrease in platelet production or an increase in the rate of platelet destruction.
Highly specific evaluation of thrombocytopenia
Immune Thrombocytopenic Purpura (ITP) is an autoimmune disorder characterised by a low platelet count and mucocutaneous bleeding. The autoantibodies are directed primarily to the platelet-specific receptors CD41a (GPIIb/IIIa) and CD42b (GPIb).
As a result, the sensitized platelets are rapidly cleared by the monocyte-macrophage cell systems. The determination of autoantibodies against thrombocytes allows differentiate immune from nonimmune thrombocytopenia.
Anti-human Igs specificity analysis shows a very low cross-reactivity (>7%) for all of them, making easy the correct identification of non-pathological sample.
