196,00 € – 375,00 €
This antibody reacts with the CD49d antigen, which recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and ß subunits and is involved in cell–cell and cell–extracellular matrix interactions. The ß-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein.
The CD29 antigen, also known as the ß-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ß integrin, forms a lymphocyte homing receptor for Peyer’s patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
|Storage||Store in the dark at 2-8°C.|
Alpha-4 integrin chain; VLA-4 alpha chain, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha.
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide (NaN3).
Tissue / cell preparation (JM leukemia line).
Please refer to the Certificate of Analysis for the lot-specific concentration. Typically 0,05 mg/ml.