TCR CBeta 2

The recombinant monoclonal antibody SAM.2.rMAb specifically recognises the TCR Cβ2 constant region, which is present on a significant proportion of CD4+ and CD8+ T cells. The T-cell receptor (TCR αβ), composed of α and β chains, plays a key role in the adaptive immune response by recognising antigens presented by the MHC. While the TCR β constant region can be derived from either the TCRB1 (Cβ1) or TCRB2 (Cβ2) genes, the JOVI.1 antibody specifically recognises the Cβ1 region. Both antibodies are used in flow cytometry to differentiate T-cell subsets. However, some CD3- and TCR-specific antibodies may not be compatible with SAM.2.rMAb, so it is essential to validate their use in co-marking studies.