Anti- Human HLA-B27 (HLA-ABC-m3)

SKU: HLAB27F-100T Category:

520,00  excl.VAT

The monoclonal antibody Anti-HLA-B27 is directed against the HLA-B27 antigen, a class I surface molecule encoded by the B locus of the human Major Histocompatibility Complex (MHC). This antigen plays a key role in the presentation of microbial peptides to T cells, contributing to immune recognition and response 1.

HLA-B27 is expressed in approximately 7% of the Caucasian population, while a related antigen, HLA-B7, is found in about 22%2. The detection of HLA-B27 is clinically significant due to its strong association with inflammatory diseases, particularly ankylosing spondylitis. Over 90% of individuals diagnosed with ankylosing spondylitis express the HLA-B27 antigen, compared to only 7% of asymptomatic individuals3. This monoclonal antibody enables the identification of HLA-B27 specificity within the class I HLA allotype, supporting the diagnosis and monitoring of spondyloarthropathies. Flow cytometry using CYT HLAIB27F provides a rapid and reliable method for assessing HLA-B27 expression in clinical samples 3.

Furthermore, structural and functional studies have shown that HLA-B27 may contribute to disease pathogenesis through mechanisms involving misfolding, aberrant immune responses, and interactions with innate immune receptors.

Additional information

Clone

Isotype

Conjugated

Size

Regulatory Status

Format

Storage Store in the dark at 2-8 ºC
Other names

HLA class I histocompatibility antigen, B alpha chain, HLA-B, HLAB

Buffer

Aqueous buffered solution containing protein stabilizer and 0.09% sodium azide (NaN3).

Immunogen

Immune complex precipitated from HLA-B27 positive cell line (Bordin).