Blog | Immunostep Biotech

HLA-DR as a dynamic biomarker: limitations and new interpretations in clinical immunology

The human immune system is, by definition, dynamic. However, for many years clinical immunology has attempted to describe it using static biomarkers, single time-point measurements intended to summarize...

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Off-the-Shelf Cell Therapies: Current Status and Challenges

Publicado en Immunología.

Cell therapies have transformed immuno-oncology and regenerative medicine, with autologous CAR-T therapies being the most recognized for their clinical efficacy. However, the need for fast, scalable,...

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The tumour microenvironment and NK cell suppression: key mechanisms and immunosuppressive

Publicado en Immunología.

The tumour microenvironment (TME) constitutes a highly dynamic ecosystem in which tumour, stromal and immune cells interact in complex ways. In this context, NK (Natural Killer) cells—essential components...

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Exosomes in therapy resistance: transfer of miRNAs and proteins associated with resistant phenotypes

Publicado en Exosomas.

Therapy resistance is one of the main obstacles in the treatment of complex diseases such as cancer. As our understanding of the mechanisms involved deepens, exosomes have taken on an increasingly prominent...

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Exosomes as mediators of tumour crosstalk: functional hubs in the dynamics of the microenvironment

Publicado en Exosomas.

The tumour microenvironment (TME) constitutes a highly organised system of intercellular communication, in which the transfer of information is as decisive as the genetic alterations inherent to tumour...

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Tumour exosomes as a source of liquid biopsy: the future of diagnosis in oncology

Publicado en Exosomas.

https://youtu.be/Q87npv5qAQc The use of tumour exosomes as a source of liquid biopsy has become one of the most promising advances in the diagnosis and monitoring of cancer. Tumour cells release exosomes,...

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Immunometabolism and functional fitness in cell therapies: cutting-edge perspectives for the optimisation of CAR-T cells

Publicado en Immunología.

CAR-T cell therapy and other adoptive immunotherapy strategies have revolutionised the treatment of refractory haematological malignancies and certain solid tumours. However, the efficacy of these therapies...

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Exhaustion vs. Dysfunction in CAR-T Cells: Emerging Biomarkers That Are Redefining Their Functional Assessment

Publicado en Immunología.

CAR-T cell therapy has established itself as one of the most significant advances in modern immunotherapy. In recent years, it has transformed the treatment of numerous hematologic malignancies, particularly...

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NK cells in clinical practice: towards the therapeutic standardisation of cellular immunotherapy

Publicado en Immunología.

Natural killer (NK) cells have emerged as one of the most promising components of cellular immunotherapy, thanks to their unique ability to identify and eliminate tumour cells independently of classical...

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Spreading error as an experimental variable: How to quantify it and use it to optimize cytometry panels

Publicado en Immunología.

In high-dimensional flow cytometry, the concept of spreading error is often mentioned in passing. Most discussions focus on spillover, the classical overlap of fluorochrome emission spectra, but spreading...

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HLA-DR as a dynamic biomarker: limitations and new interpretations in clinical immunology

Off-the-Shelf Cell Therapies: Current Status and Challenges

The tumour microenvironment and NK cell suppression: key mechanisms and immunosuppressive

Exosomes in therapy resistance: transfer of miRNAs and proteins associated with resistant phenotypes

Exosomes as mediators of tumour crosstalk: functional hubs in the dynamics of the microenvironment

Tumour exosomes as a source of liquid biopsy: the future of diagnosis in oncology

Immunometabolism and functional fitness in cell therapies: cutting-edge perspectives for the optimisation of CAR-T cells

Exhaustion vs. Dysfunction in CAR-T Cells: Emerging Biomarkers That Are Redefining Their Functional Assessment

NK cells in clinical practice: towards the therapeutic standardisation of cellular immunotherapy

Spreading error as an experimental variable: How to quantify it and use it to optimize cytometry panels

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