The immune system is often described as a highly specialized defense network designed to recognize and eliminate abnormal cells. However, recent advances in tumor immunology have revealed that immune...
The evolution of high-parameter flow cytometry has enabled the development of increasingly complex panels capable of characterizing extremely rare cell populations with unprecedented depth. However,...
Cancer does not progress in isolation. On the contrary, it builds around itself a complex ecosystem in which tumor, stromal, and immune cells constantly interact. Within this context, exosomes have...
T cell exhaustion has become one of the most relevant concepts in modern immunology, particularly in the context of cancer, chronic infections, and cellular therapies such as CAR-T. As our understanding...
The analysis of extracellular vesicles at the single-particle level (single-EV analysis) has rapidly evolved from a technological ambition into a scientific necessity. As the extracellular vesicle field...
In flow cytometry, the use of Annexin V has become one of the most widely adopted approaches for the analysis of cell death, particularly in the study of apoptosis. Its methodological basis, centered...
The human immune system is, by definition, dynamic. However, for many years clinical immunology has attempted to describe it using static biomarkers, single time-point measurements intended to summarize...
Cell therapies have transformed immuno-oncology and regenerative medicine, with autologous CAR-T therapies being the most recognized for their clinical efficacy. However, the need for fast, scalable,...
The tumour microenvironment (TME) constitutes a highly dynamic ecosystem in which tumour, stromal and immune cells interact in complex ways. In this context, NK (Natural Killer) cells—essential components...
Therapy resistance is one of the main obstacles in the treatment of complex diseases such as cancer. As our understanding of the mechanisms involved deepens, exosomes have taken on an increasingly prominent...