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How to assess T cell exhaustion by flow cytometry

T cell exhaustion has become one of the most relevant concepts in modern immunology, particularly in the context of cancer, chronic infections, and cellular therapies such as CAR-T. As our understanding...

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Single-EV Analysis: Where Is the Field Heading?

Publicado en Exosomas.

The analysis of extracellular vesicles at the single-particle level (single-EV analysis) has rapidly evolved from a technological ambition into a scientific necessity. As the extracellular vesicle field...

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Annexin V is not enough: distinguishing apoptosis, necroptosis, and pyroptosis in flow cytometry

Publicado en Immunología.

In flow cytometry, the use of Annexin V has become one of the most widely adopted approaches for the analysis of cell death, particularly in the study of apoptosis. Its methodological basis, centered...

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HLA-DR as a dynamic biomarker: limitations and new interpretations in clinical immunology

Publicado en Immunología.

The human immune system is, by definition, dynamic. However, for many years clinical immunology has attempted to describe it using static biomarkers, single time-point measurements intended to summarize...

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Off-the-Shelf Cell Therapies: Current Status and Challenges

Publicado en Immunología.

Cell therapies have transformed immuno-oncology and regenerative medicine, with autologous CAR-T therapies being the most recognized for their clinical efficacy. However, the need for fast, scalable,...

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The tumour microenvironment and NK cell suppression: key mechanisms and immunosuppressive

Publicado en Immunología.

The tumour microenvironment (TME) constitutes a highly dynamic ecosystem in which tumour, stromal and immune cells interact in complex ways. In this context, NK (Natural Killer) cells—essential components...

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Exosomes in therapy resistance: transfer of miRNAs and proteins associated with resistant phenotypes

Publicado en Exosomas.

Therapy resistance is one of the main obstacles in the treatment of complex diseases such as cancer. As our understanding of the mechanisms involved deepens, exosomes have taken on an increasingly prominent...

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Exosomes as mediators of tumour crosstalk: functional hubs in the dynamics of the microenvironment

Publicado en Exosomas.

The tumour microenvironment (TME) constitutes a highly organised system of intercellular communication, in which the transfer of information is as decisive as the genetic alterations inherent to tumour...

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Tumour exosomes as a source of liquid biopsy: the future of diagnosis in oncology

Publicado en Exosomas.

https://youtu.be/Q87npv5qAQc The use of tumour exosomes as a source of liquid biopsy has become one of the most promising advances in the diagnosis and monitoring of cancer. Tumour cells release exosomes,...

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Immunometabolism and functional fitness in cell therapies: cutting-edge perspectives for the optimisation of CAR-T cells

Publicado en Immunología.

CAR-T cell therapy and other adoptive immunotherapy strategies have revolutionised the treatment of refractory haematological malignancies and certain solid tumours. However, the efficacy of these therapies...

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How to assess T cell exhaustion by flow cytometry

Single-EV Analysis: Where Is the Field Heading?

Annexin V is not enough: distinguishing apoptosis, necroptosis, and pyroptosis in flow cytometry

HLA-DR as a dynamic biomarker: limitations and new interpretations in clinical immunology

Off-the-Shelf Cell Therapies: Current Status and Challenges

The tumour microenvironment and NK cell suppression: key mechanisms and immunosuppressive

Exosomes in therapy resistance: transfer of miRNAs and proteins associated with resistant phenotypes

Exosomes as mediators of tumour crosstalk: functional hubs in the dynamics of the microenvironment

Tumour exosomes as a source of liquid biopsy: the future of diagnosis in oncology

Immunometabolism and functional fitness in cell therapies: cutting-edge perspectives for the optimisation of CAR-T cells

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