Systemic lupus erythematosus (SLE) is a complex, multisystemic, and highly heterogeneous autoimmune disease. Its diagnosis and clinical monitoring have traditionally been challenging due to the variability...
In the era of personalised medicine, the most valuable information is not always in an MRI, blood test or biopsy. Often, it lies deep within our cells, even before the disease manifests itself clinically.
Thanks...
Immunotherapy has transformed cancer treatment in the last decade, especially thanks to immune checkpoint inhibitors such as anti-PD-1, anti-PD-L1 or anti-CTLA-4. However, not all patients respond,...
Regulation (EU) 2017/746 on in vitro diagnostic medical devices (known as IVDR) represents a profound change in the regulation of the diagnostic sector in Europe. Replacing the previous Directive 98/79/EC...
In science, predicting the future is not a matter of crystal balls, but of data, technology and molecular knowledge. Now, thanks to modern biotechnology, we can detect subtle biological signals long...
Cell death is neither a binary phenomenon nor an instantaneous event. Before a cell dies-whether from a physiological or pathological stimulus-complex, carefully orchestrated molecular pathways are...
Flow cytometry is an extremely powerful tool for cell analysis, but it is also surprisingly easy to make mistakes that compromise your results, even without realizing it. A bad setup, an inadequate...
CAR-T therapy has revolutionised the treatment of certain haematological cancers, such as acute lymphoblastic leukaemia and B-cell lymphoma. However, recent advances have allowed its application to...
Researchers widely use freeze-drying to preserve biomaterials, including biological nanoparticles such as exosomes, liposomes, and protein nanoparticles. However, this process can induce alterations...
Isolation of exosomes is a fundamental step in the investigation of cellular biogenesis, biomarkers and potential therapeutic applications. There are several methods to carry out this task, but two...