In the field of immunology, precision in cell detection and analysis is essential. Fluorescent Streptavidin Dextrans from Immunostep offer an advanced solution to enhance signal detection in flow cytometry applications, especially for identifying specific B cells and monitoring advanced therapies such as CAR-T cells.
What Are Fluorescent Streptavidin Dextrans?
Fluorescent Streptavidin Dextrans are complexes combining fluorescent dextrans with streptavidin, a protein with high affinity for biotin. This system allows for efficient signal amplification and flexible detection of biotinylated targets, surpassing the limitations of conventional direct conjugation methods.
Main Applications
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Detection of Specific B Cells: Enables identification of specific cell populations, even at low concentrations, improving accuracy in immunological studies.
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CAR-T Therapy Monitoring: Facilitates more effective tracking of CAR-T cells in treatments against leukemia and other hematological cancers.
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Immune Response Research: Supports the study of immune responses under various pathological conditions, providing more precise and reproducible data.
Advantages of the Dextran-Streptavidin System
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High Affinity and Specificity: The biotin-streptavidin interaction ensures strong, specific binding, minimizing non-specific interactions.
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Detection Flexibility: Compatible with multiple fluorochromes such as FITC, PE, and APC, adapting to researcher needs.
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Improved Sensitivity: Signal amplification enhances detection of rare events, crucial in stem cell and gene therapy studies.
Available Products
Immunostep offers the following Fluorescent Streptavidin Dextrans:
These products are designed to deliver consistent, high-quality results in flow cytometry applications.
Conclusion
Fluorescent Streptavidin Dextrans are not only an advancement in flow cytometry but also play a crucial role in translational research and the development of advanced cell therapies, such as CAR-T therapies. Their ability to generate clear and reproducible signals enables precise tracking of specific cell populations, facilitating the assessment of efficacy and safety in innovative treatments in both preclinical and clinical settings.
Moreover, the versatility of these fluorescent dextrans allows the combination of multiple fluorochromes, optimizing complex protocols and increasing assay sensitivity without compromising cell viability. This is particularly relevant for monitoring genetically modified cells, detecting rare cells, and studying dynamic immune responses in real time.
Ultimately, incorporating Fluorescent Streptavidin Dextrans into laboratory workflows helps bridge the gap between basic research and clinical applications, providing high-resolution data that support informed clinical decisions and advance the development of safer and more effective therapies. Their strategic use positions Immunostep as a key partner for laboratories and research centers focused on innovation in immunology and cellular medicine.