CD42b

Reacts with a two chain membrane glycoprotein, GpIb, that forms a non covalent complex with GPIX (CD42a) found on platelets and magakaryocytes. Clone HIP1 antibody inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets, ristocetin-induced platelet agglutination and partially inhibits collagen induced aggregation. The GPIb/IX complex serves as the vWF surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls. (1-5)