IgM is the first antibody produced in a primary immune response and circulates mainly as a high-avidity pentamer. It efficiently activates the classical complement pathway and is also expressed on na\u00efve B cells as part of the B-cell receptor. Anti-human IgM monoclonal antibodies specifically recognize the \u03bc heavy chain and are widely used in flow cytometry and immunofluorescence to identify IgM+ B cells in studies of B-cell maturation, immune function, and related disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"
Immunoglobulin (Ig) G (IgG) is the predominant of five classes of Ig (IgG, IgA, IgM, IgE, and IgD). Igs differ in heavy chain structure and effector function.
\nIn normal adults, IgG3 represents~4% of serum IgG. IgG3 activates complement more readily than other IgG subclasses, has high affinity for Fc receptors on agocytes (Fc\u03b3R), crosses the placenta less readily than IgG1 and IgG4 but more so than IgG2, and has an overall half-life of~7 days. Some adults with frequent or severe\u00a0 respiratory tract infection have subnormal IgG3 (<2 SD below respective means) (1-2)<\/p>\n
Immunoglobulin M (IgM) represents the primary antibody produced during an initial immune response. Structurally, IgM is a pentameric molecule composed of five immunoglobulin units linked by a joining (J) chain, providing it with high avidity for antigens. Owing to its multivalent structure, IgM is highly efficient in activating the classical complement pathway and in promoting agglutination and neutralization of pathogens. In healthy individuals, IgM accounts for approximately 5\u201310% of total serum immunoglobulins and is predominantly expressed on the surface of na\u00efve B lymphocytes as a membrane-bound form (mIgM), where it functions as part of the B-cell receptor (BCR) complex.<\/p>\n
Upon antigen encounter, IgM plays a key role in the initiation of humoral immune responses and the activation of downstream signaling pathways leading to B-cell\u00a0 differentiation and antibody production. The anti-human IgM monoclonal antibody specifically recognizes the \u03bc heavy chain of human IgM and does not cross-react with other immunoglobulin isotypes (IgG, IgA, IgE, or IgD).<\/p>\n
When used in flow cytometry or immunofluorescence assays, it enables the identification and quantification of IgM-expressing B cells, facilitating studies of B-cell maturation, immune competence, and abnormal immunoglobulin expression associated with immunodeficiencies, autoimmune diseases, and B-cell malignancies.<\/p>\n","protected":false},"featured_media":26958,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_links_to":"","_links_to_target":""},"product_line":[2167],"product_cat":[2172],"product_tag":[],"class_list":{"0":"post-38344","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_line-immunology","7":"product_cat-single-antibodies","8":"pa_clone-mhm-88","9":"pa_conjugated-percp-cyanine5-5","10":"pa_gene-id-2391","11":"pa_isotype-mouse-igg1-kappa","12":"pa_regulatory-status-ruo","13":"pa_species-reactivity-human","15":"first","16":"instock","17":"taxable","18":"shipping-taxable","19":"purchasable","20":"product-type-simple"},"yoast_head":"\n