The monoclonal antibody Anti-HLA-B27 is directed against the HLA-B27 antigen, a class I surface molecule encoded by the B locus of the human Major Histocompatibility Complex (MHC). This antigen plays a key role in the presentation of microbial peptides to T cells, contributing to immune recognition and response 1.<\/p>\n
HLA-B27 is expressed in approximately 7% of the Caucasian population, while a related antigen, HLA-B7, is found in about 22%2. The detection of HLA-B27 is clinically significant due to its strong association with inflammatory diseases, particularly ankylosing spondylitis. Over 90% of individuals diagnosed with ankylosing spondylitis express the HLA-B27 antigen, compared to only 7% of asymptomatic individuals3. This monoclonal antibody enables the identification of HLA-B27 specificity within the class I HLA allotype, supporting the diagnosis and monitoring of spondyloarthropathies. Flow cytometry using CYT HLAIB27F provides a rapid and reliable method for assessing HLA-B27 expression in clinical samples 3.<\/p>\n
Furthermore, structural and functional studies have shown that HLA-B27 may contribute to disease pathogenesis through mechanisms involving misfolding, aberrant immune responses, and interactions with innate immune receptors.<\/p>\n","protected":false},"excerpt":{"rendered":"
The monoclonal antibody Anti-HLA-B27 targets the HLA-B27 antigen, a class I MHC molecule essential for presenting microbial peptides to T cells. HLA-B27 is present in about 7% of Caucasians and is strongly associated with inflammatory disorders, especially ankylosing spondylitis\u2014over 90% of patients with this condition express HLA-B27. Detection of this antigen, particularly via flow cytometry using CYT HLAIB27F, is crucial for diagnosing and monitoring spondyloarthropathies. Additionally, HLA-B27’s role in disease pathogenesis may involve protein misfolding, immune dysregulation, and interactions with innate immunity.<\/p>\n","protected":false},"featured_media":37096,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_links_to":"","_links_to_target":""},"product_line":[2167],"product_cat":[2172],"product_tag":[],"class_list":{"0":"post-34754","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_line-immunology","7":"product_cat-single-antibodies","8":"pa_clone-hla-abc-m3","9":"pa_conjugated-fitc","10":"pa_format-liquid","11":"pa_isotype-mouse-igg2a","12":"pa_protocol-sm","13":"pa_regulatory-status-ruo","14":"pa_size-100-test","15":"pa_volumen-test-20-l-test","17":"first","18":"instock","19":"taxable","20":"shipping-taxable","21":"purchasable","22":"product-type-simple"},"yoast_head":"\n