CD185, a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt\u2019s lymphoma cells, and a subset of neurons. It plays a crucial role in directing cell migration to the B cell follicles within secondary lymphoid organs, which are key sites for initiating immune responses.<\/p>\n
The ligand for the CXCR5 chemokine receptor is CXCL13 (also known as B-lymphocyte chemoattractant or BLC). CXCR5 plays an important role in the positioning and cognate interactions of B-cell chronic lymphocytic leukemia (CLL) cells with CXCL13-secreting CD68+ accessory cells within the lymphoid tissues. This interaction helps support the survival and proliferation of CLL cells in their protective microenvironment.<\/p>\n
The high expression of CXCR5 on T follicular helper cells (T(FH)) and a subset of central memory CD4 T cells (T(CM)), suggesting that CXCR5(+) T(CM) may function similarly to T(FH) cells in supporting humoral immune responses. CXCR5(+) T(CM) exhibit B cell helper qualities, expressing high levels of CXCL13, inducing plasma cell differentiation and Ig secretion, and showing responsiveness to ICOS ligand costimulation and IL-10 secretion. These attributes are acquired through interaction with B cells, indicating a specialized role in promoting quick and efficient secondary humoral immune responses. In conclusion, CXCR5(+) T(CM) are proposed as a distinct memory cell subset specialized in supporting antibody-mediated immune responses.<\/p>\n","protected":false},"excerpt":{"rendered":"
CD185, a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt\u2019s lymphoma cells, and a subset of neurons. It plays a crucial role in directing cell migration to the B cell follicles within secondary lymphoid organs, which are key sites for initiating immune […]<\/p>\n","protected":false},"featured_media":31523,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_links_to":"","_links_to_target":""},"product_line":[2167,2166],"product_cat":[2175,2172],"product_tag":[],"class_list":{"0":"post-28538","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_line-immunology","7":"product_line-oncohematology","8":"product_cat-euroflow","9":"product_cat-single-antibodies","10":"pa_clonality-monoclonal","11":"pa_clone-j252d4","12":"pa_conjugated-apc","13":"pa_format-liquid","14":"pa_gene-id-2109","15":"pa_isotype-mouse-igg1-kappa","16":"pa_population-b-cell","17":"pa_population-dendrititic-cell","18":"pa_population-nk-cell","19":"pa_population-t-cell","20":"pa_regulatory-status-ruo","21":"pa_size-100-test","22":"pa_species-reactivity-human","23":"pa_tested-applications-fcm","24":"pa_volumen-test-20-l-test","26":"first","27":"instock","28":"taxable","29":"shipping-taxable","30":"purchasable","31":"product-type-variable"},"yoast_head":"\n