{"id":39587,"date":"2026-04-09T13:40:35","date_gmt":"2026-04-09T11:40:35","guid":{"rendered":"https:\/\/immunostep.com\/?page_id=39587"},"modified":"2026-04-09T14:26:52","modified_gmt":"2026-04-09T12:26:52","slug":"complejo-cd3","status":"publish","type":"page","link":"https:\/\/immunostep.com\/es\/complejo-cd3\/","title":{"rendered":"COMPLEJO CD3"},"content":{"rendered":"<div>\n<h1>Detecci\u00f3n de la clonalidad de las c\u00e9lulas T:<\/h1>\n<\/div>\n<div>\n<p>La identificaci\u00f3n exhaustiva de los subconjuntos de c\u00e9lulas T permite realizar diagn\u00f3sticos de c\u00e1ncer m\u00e1s precisos.<\/p>\n<p>Para ello, ofrecemos reactivos de alta especificidad y sensibilidad que permiten realizar an\u00e1lisis eficaces y seguros mediante citometr\u00eda de flujo.<\/p>\n<\/p>\n<\/div>\n<p>\n    <a href=\"#findout\">Descubre c\u00f3mo funciona<\/a>\n<\/p>\n<div>\n<\/p>\n<p style=\"text-align: center;\">El complejo <b>CD3-TCR<\/b> interviene en el desarrollo y la activaci\u00f3n de los linfocitos T.<\/p>\n<p style=\"text-align: center;\">Est\u00e1 formado por la <b>mol\u00e9cula dim\u00e9rica TCR<\/b> (receptor de c\u00e9lulas T) y la <b>mol\u00e9cula hexam\u00e9rica CD3.<\/b><\/p>\n<p style=\"text-align: center;\"><b>CD3<\/b> est\u00e1 formado por cuatro cadenas diferentes, \u03b3, \u03b4, \u03b5 y \u03b6, que se combinan para formar 3 d\u00edmeros: un <b>homod\u00edmero \u03b6\/\u03b6<\/b> y <b>dos heterod\u00edmeros<\/b>, <b>\u03b3\/\u03b5 y \u03b4\/\u03b5.<\/b><\/p>\n<p style=\"text-align: center;\">Las cadenas \u03b3, \u03b4 y \u03b5 tienen una regi\u00f3n <b>ITAM<\/b> (motivo inmunoestimulador basado en tirosina), y la cadena \u03b6 tiene tres ITAM; esta regi\u00f3n interviene en la activaci\u00f3n celular. El complejo CD3 act\u00faa como correceptor del TCR cuando reconoce un ant\u00edgeno y participa en la se\u00f1alizaci\u00f3n interna de los linfocitos.<\/p>\n<p style=\"text-align: center;\">El TCR puede estar formado por una <b>cadena \u03b1<\/b> y una <b>cadena \u03b2 (TCR \u03b1\/\u03b2)<\/b> o por una cadena \u03b3 y una cadena \u03b4 (TCR \u03b3\/\u03b4), siendo la mayor\u00eda de los linfocitos T de la sangre perif\u00e9rica del tipo \u03b1\/\u03b2 y los del tipo \u03b3\/\u03b4 m\u00e1s abundantes en el tejido epitelial. Ambas cadenas tienen una regi\u00f3n constante (C) y una regi\u00f3n variable (V), correspondiendo esta \u00faltima al sitio de uni\u00f3n al ant\u00edgeno que recibe el p\u00e9ptido presentado por el <b>MHC (Complejo Mayor de Histocompatibilidad)<\/b> de las c\u00e9lulas presentadoras de ant\u00edgenos.<\/p>\n<p style=\"text-align: center;\">En el caso del <b>TCR \u03b1\/\u03b2,<\/b> la regi\u00f3n constante de la cadena \u03b2 presenta dos tipos, \u03b21 o \u03b22, por lo que se pueden distinguir dos poblaciones de <b>linfocitos T \u03b1\/\u03b2: TCR C\u03b21 (o TRBC1) y TCR C\u03b22 (o TRBC2).<\/b><\/p>\n<\/div>\n<div>\n<h1>Complejo CD3-TCR<\/h1>\n<\/div>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/2026\/04\/FINAL-FLYER-7.png\" alt=\"\"><\/p>\n<ul>\n<li>\n<h3>CD3\u03b4<\/h3>\n<div>\n<p>Adem\u00e1s de su papel en la activaci\u00f3n, interviene en el correcto <b>ensamblaje de los receptores de c\u00e9lulas T (TCR)<\/b> y en su expresi\u00f3n extracelular a trav\u00e9s de la <b>v\u00eda de activaci\u00f3n de la ERK (quinasa regulada por se\u00f1ales extracelulares)<\/b>, lo cual es importante para la selecci\u00f3n positiva de los timocitos.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>CD3\u03b5<\/h3>\n<div>\n<p>Desempe\u00f1a un papel en la regulaci\u00f3n de la <b>expresi\u00f3n del TCR<\/b> y en la selecci\u00f3n negativa t\u00edmica, y es un componente clave de la se\u00f1alizaci\u00f3n celular.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>CD3\u03b3<\/h3>\n<div>\n<p>Desempe\u00f1a un papel en la activaci\u00f3n celular, en el ensamblaje inicial del TCR y en la regulaci\u00f3n de su expresi\u00f3n en la superficie celular <b>a trav\u00e9s de la v\u00eda de activaci\u00f3n de la ERK (quinasa regulada por se\u00f1ales extracelulares)<\/b>.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>CD3\u03b6<\/h3>\n<div>\n<p><b>El d\u00edmero \u03b6\u03b6, CD247,<\/b> tiene tres ITAM por cadena y participa tanto en la activaci\u00f3n celular como en la diferenciaci\u00f3n intrat\u00edmica.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>ITAM (Immunoreceptor Tyrosine-based Activation Motif)<\/h3>\n<div>\n<p>V\u00edas de se\u00f1alizaci\u00f3n celular que, mediante la fosforilaci\u00f3n por parte de tirosina quinasas espec\u00edficas, permiten la <b>activaci\u00f3n celular<\/b>.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>CD3<\/h3>\n<div>\n<p>Una mol\u00e9cula esencial para el <b>ensamblaje y la regulaci\u00f3n del TCR<\/b> y para la <b>activaci\u00f3n de los linfocitos T<\/b>. Est\u00e1 formada por seis cadenas: \u03b3, \u03b4, \u03b5 (dos cadenas) y \u03b6 (dos cadenas).<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>TCR (T Cell Receptor)<\/h3>\n<div>\n<p>Posee sitios de uni\u00f3n espec\u00edficos en su regi\u00f3n variable para los ant\u00edgenos presentados por las c\u00e9lulas a trav\u00e9s de la <b>interacci\u00f3n MHC-TCR,<\/b> lo que permite el reconocimiento espec\u00edfico y la activaci\u00f3n funcional de la c\u00e9lula para desencadenar una respuesta inmunitaria. Est\u00e1 compuesto por una <b>cadena \u03b1<\/b> y una <b>cadena \u03b2;<\/b> esta \u00faltima puede clasificarse como \u03b21 o \u03b22.<\/p>\n<\/div>\n<\/li>\n<\/ul>\n<hr>\n<div>\n<h5 class=\"uk-heading-bullet uk-text-center\" data-id=\"page#6-0-1-0\">CONTEXTO\/RELEVANCIA CL\u00cdNICA<\/h5>\n<\/div>\n<div>\n<p>El diagn\u00f3stico de las neoplasias de c\u00e9lulas T se ha beneficiado enormemente del desarrollo de anticuerpos dirigidos contra la regi\u00f3n constante de la cadena \u03b2 (C\u03b2) de la mol\u00e9cula del receptor de c\u00e9lulas T (TCR), lo que ha permitido analizar la distribuci\u00f3n de las poblaciones C<i>\u03b2<\/i>1 y C<i>\u03b22<\/i> e identificar anomal\u00edas que puedan indicar una enfermedad.<\/p>\n<\/div>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/2026\/04\/TCR-C%CE%B221.png\" alt=\"TCR C\u03b22\"><\/p>\n<div>\n<\/p>\n<p>Este m\u00e9todo de detecci\u00f3n es similar al modelo de diagn\u00f3stico de la neoplasia de c\u00e9lulas B, que se basa en la restricci\u00f3n de las cadenas ligeras de inmunoglobulina de membrana a las cadenas kappa (<i>\u03ba<\/i>) o lambda (<i>\u03bb<\/i>).<\/p>\n<p>El uso simult\u00e1neo de ambos anticuerpos (TCR C<i>\u03b2<\/i>1 y TCR C<i>\u03b2<\/i>2) garantiza la separaci\u00f3n correcta y espec\u00edfica de las poblaciones para identificar con precisi\u00f3n la relaci\u00f3n entre ambas.<\/p>\n<p>De este modo, es posible detectar si existe clonalidad, es decir, una distribuci\u00f3n completa o abrumadoramente predominante hacia un \u00fanico tipo de cadena <i>\u03b2<\/i>, lo que podr\u00eda ser indicativo de una neoplasia de c\u00e9lulas T.<\/p>\n<\/p>\n<\/div>\n<p>\n    <a href=\"https:\/\/immunostep.com\/es\/immunostep\/contacto\/\">CONTACTA CON NUESTROS EXPERTOS<\/a>\n<\/p>\n<div>\n<h5 class=\"uk-heading-bullet uk-text-center\" data-id=\"page#6-0-1-0\" style=\"text-align: center;\">AN\u00c1LISIS ESTRAT\u00c9GICO<\/h5>\n<\/div>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/2026\/04\/TCR-Landing.pptx.jpg\" alt=\"\"><\/p>\n<div>\n<h6 style=\"text-align: center;\">Ejemplo de una estrategia de an\u00e1lisis para un donante sano muestra de sangre perif\u00e9rica; se ha detectado clonalidad de las c\u00e9lulas T colaboradoras (CD4+) TCR C\u03b22).<\/h6>\n<p>En el caso de los linfocitos T, la poblaci\u00f3n espec\u00edfica se identifica mediante <b>anti-CD3<\/b> y las subpoblaciones se analizan seg\u00fan pertenezcan al <b>TCR C<i>\u03b2<\/i>1<\/b> o al <b>TCR C<i>\u03b2<\/i>2<\/b>. Es recomendable realizar un inmunofenotipado m\u00e1s preciso, separando primero las poblaciones de TCR <i>\u03b1\/\u03b2<\/i> y TCR <i>\u03b3\/\u03b4<\/i>, para identificar posteriormente las subpoblaciones de TCR <i>\u03b1\/\u03b2<\/i>: <b>CD4+\/CD8-<\/b> (c\u00e9lulas T colaboradoras o Th), <b>CD4-\/CD8+<\/b> (c\u00e9lulas T citot\u00f3xicas o Tc), <b>CD4-\/CD8-<\/b> (c\u00e9lulas T doblemente negativas o DN) y <b>CD4+\/CD8+<\/b> (c\u00e9lulas T doblemente positivas o DP).<\/p>\n<p><b>Los linfocitos T TCR <i>\u03b3\/\u03b4<\/i><\/b> identificados tambi\u00e9n pueden analizarse junto con los dem\u00e1s marcadores auxiliares.<\/p>\n<p>El uso de reactivos auxiliares permite un diagn\u00f3stico m\u00e1s fiable y preciso, ya que proporciona informaci\u00f3n detallada sobre todas las poblaciones posibles y su cuantificaci\u00f3n exacta. Es adecuado utilizar anticuerpos <b>TCR <i>\u03b1\/\u03b2<\/i>, TCR <i>\u03b3\/\u03b4<\/i>, CD4 y CD8<\/b> en combinaci\u00f3n con <b>TCR C<i>\u03b2<\/i>1 y C<i>\u03b2<\/i>2<\/b>, y otros marcadores de poblaci\u00f3n (tanto espec\u00edficos de c\u00e9lulas T como no espec\u00edficos) y marcadores de maduraci\u00f3n para detectar una expresi\u00f3n an\u00f3mala o ausente, lo que proporciona una interpretaci\u00f3n m\u00e1s completa y sensible.<\/p>\n<\/div>\n<h5>REFERENCIAS DE PRODUCTO<\/h5>\n<table>\n<thead>\n<tr>\n<th>Product name<\/th>\n<th>Reference<\/th>\n<th>Description<\/th>\n<th><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>TCR CBeta 1<\/td>\n<td>PJOVI<\/td>\n<td>\n<p>El anticuerpo monoclonal JOVI.1 reconoce un ep\u00edtopo com\u00fan a una gran proporci\u00f3n de linfocitos T CD4+ o CD8+ humanos que expresan la cadena beta del receptor de c\u00e9lulas T (TCR\u03b2)<\/p>\n<\/td>\n<td>\n        <a href=\"https:\/\/immunostep.com\/product\/tcr-cbeta1\/?v=12470fe406d4\">Ver en la tienda<\/a>\n    <\/td>\n<\/tr>\n<tr>\n<td>TCR CBeta 2<\/td>\n<td>TCRCB2PE<\/td>\n<td>\n<p>El anticuerpo monoclonal recombinante SAM.2.rMAb reconoce espec\u00edficamente la regi\u00f3n constante C\u03b22 del TCR<\/p>\n<\/td>\n<td>\n        <a href=\"https:\/\/immunostep.com\/product\/anti-human-t-cr-c%ce%b2-2-sam-2-rmab\/?v=12470fe406d4\">Ver en la tienda<\/a>\n    <\/td>\n<\/tr>\n<tr>\n<td>TCRa\/b<\/td>\n<td>TCRABPE<\/td>\n<td>\n<p>Este anticuerpo se dirige contra un determinante de la regi\u00f3n constante presente en la superficie de todos los linfocitos T que expresan el TCR \u03b1\/\u03b2 1<\/p>\n<\/td>\n<td>\n        <a href=\"https:\/\/immunostep.com\/product\/anti-human-%ce%b1%ce%b2-t-cell-receptor-ip26\/?v=12470fe406d4\">Ver en la tienda<\/a>\n    <\/td>\n<\/tr>\n<tr>\n<td>TCRg\/d<\/td>\n<td>TCRGD<\/td>\n<td>\n<p>El TCR \u03b3\/\u03b4 es una glicoprote\u00edna heterodim\u00e9rica que se une de forma no covalente al ant\u00edgeno CD3 1<\/p>\n<\/td>\n<td>\n        <a href=\"https:\/\/immunostep.com\/product\/tcrg-d\/?v=12470fe406d4\">Ver en la tienda<\/a>\n    <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<h5 class=\"uk-heading-bullet uk-text-center\" data-id=\"page#6-0-1-0\">RECURSOS Y MATERIALES<\/h5>\n<\/div>\n<ul>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/07\/TDS_JOVI_JOVI-1_RUO_2.pdf?v=12470fe406d4\"><\/p>\n<p>Technical Data Sheet (TDS) (RUO)\u2013 (English)- TCR Beta 1<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/01\/TDS-ANTI-HUMAN-T-CELL-RECEPTOR-SAM-2-rMAbpdf-1.pdf?v=12470fe406d4\"><\/p>\n<p>Technical Data Sheet (TDS) (RUO)\u2013(EN)- TCR Beta 2<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/03\/Anti-Human-%CE%B1%CE%B2-T-Cell-Receptor-IP26-1.pdf?v=12470fe406d4\"><\/p>\n<p>Technical Data Sheet (TDS) \u2013 (English)-TCRa\/b<\/p>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/03\/Anti-Human-\u03b1\u03b2-T-Cell-Receptor-IP26-1.pdf?v=12470fe406d4\"><strong><\/strong><\/a><\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/01\/TDS_TCRg-d-11F2-v1.docx?v=12470fe406d4\"><\/p>\n<p>Technical Data Sheet (TDS) (RUO)\u2013(English)- TCRg\/d<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/04\/TDS_TCR-CBeta1-FITC-Clon-JOVI.1-Espanol.pdf?v=12470fe406d4\"><\/p>\n<p>TDS-CE-Ficha T\u00e9cnica- TCR Beta 1<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/02\/TECHNICAL-NOTE-TCRCB2-2.pdf?v=12470fe406d4\"><\/p>\n<p>Technical note \u2013 (English)<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/MSDS_ANTIBODIES_EN_RUO.pdf?v=12470fe406d4\"><\/p>\n<p>Safety Sheet (MSDS) \u2013 (English)<\/p>\n<p><\/a><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/02\/FLYER-BETA-FINAL.pdf?v=12470fe406d4\"><\/p>\n<p>Flyer (English)<\/p>\n<p><\/a><\/p>\n<\/li>\n<\/ul>\n<hr>\n<div>\n<h1 class=\"uk-heading-bullet uk-width-2xlarge\" data-id=\"page#0-0-0-0\">Preguntas Frecuentes (FAQs)<\/h1>\n<\/div>\n<ul>\n<li>\n<h3>\u00bfSe puede utilizar cualquier anticuerpo secundario contra CD3?<\/h3>\n<div>\n<p><b>S\u00ed,<\/b> pero se recomienda utilizar los clones UCHT1 o SK7 para un mejor reconocimiento de la <b>mol\u00e9cula TCR.<\/b> Otros clones anti-CD3, como el 33-2A3, interfieren de forma m\u00e1s significativa en la uni\u00f3n de los anticuerpos anti-TCR y pueden complicar el an\u00e1lisis.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>\u00bfEs necesario utilizar ambos anticuerpos, TCR C\u03b21 y TCR C\u03b22, para identificar las poblaciones?<\/h3>\n<div>\n<p><b>No es estrictamente necesario,<\/b> pero mejora la precisi\u00f3n del diagn\u00f3stico al garantizar una separaci\u00f3n completa entre poblaciones mutuamente excluyentes.<\/p>\n<\/div>\n<\/li>\n<li>\n<h3>\u00bfPuede el procedimiento de lisis de los RBCs afectar al n\u00famero de leucocitos presentes en la muestra?<\/h3>\n<div>\n<p>No, el n\u00famero de leucocitos no se ve afectado y <strong>se recomienda lisar todas las muestras<\/strong>, de acuerdo con las <strong>directrices de EUROFLOW<\/strong>, incluyendo aquellas muestras de LCR en las que no haya contaminaci\u00f3n visible con RBCs. En este sentido, no se observan diferencias significativas entre el paso de lisis (FACS Lysing) y el paso de lavado con PBS, siendo la manipulaci\u00f3n de la muestra, y en particular la decantaci\u00f3n del sobrenadante, y no la lisis, la principal causa de p\u00e9rdida celular, por lo que se recomienda aspirar y no decantar los sobrenadantes tras los pasos de centrifugaci\u00f3n.<\/p>\n<\/div>\n<\/li>\n<\/ul>\n<hr>\n<div>\n<p><style>@import url(https:\/\/fonts.bunny.net\/css?family=sans-serif:400);<\/style>\n<style>\n#_form_172_{font-size:14px;line-height:1.6;font-family:arial, helvetica, sans-serif;margin:0;box-shadow:none}._form_hide{display:none;visibility:hidden}._form_show{display:block;visibility:visible}#_form_172_._form-top{top:0}#_form_172_._form-bottom{bottom:0}#_form_172_._form-left{left:0}#_form_172_._form-right{right:0}#_form_172_ input[type=\"text\"],#_form_172_ input[type=\"tel\"],#_form_172_ input[type=\"date\"],#_form_172_ 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(min-width:320px) and (max-width:667px){#_form_172_._inline-form._inline-style ._inline-style._button-wrapper{margin-top:20px !important;margin-left:0 !important}}#_form_172_ .iti{width:100%}#_form_172_ .iti.iti--allow-dropdown.iti--separate-dial-code{width:100%}#_form_172_ .iti input{width:100%;border:#979797 1px solid;border-radius:4px}#_form_172_ .iti--separate-dial-code .iti__selected-flag{background-color:#FFFFFF;border-radius:4px}#_form_172_ .iti--separate-dial-code .iti__selected-flag:hover{background-color:rgba(0, 0, 0, 0.05)}#_form_172_ .iti__country-list{border-radius:4px;margin-top:4px;min-width:460px}#_form_172_ .iti__country-list--dropup{margin-bottom:4px}#_form_172_ .phone-error-hidden{display:none}#_form_172_ .phone-error{color:#E40E49}#_form_172_ .phone-input-error{border:1px solid #E40E49 !important}#_form_172_._inline-form ._form-content ._form-list-subscriptions-field fieldset{margin:0;margin-bottom:1.1428571429em;border:none;padding:0}#_form_172_._inline-form 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_inline-style _clear\">\n<h2 class=\"_form-title\">\u00bfAlguna pregunta sobre nuestro complejo CD3?<\/h2>\n<\/div>\n<div class=\"_form_element _x92707266 _inline-style _clear\">\n<div class=\"_html-code\">Si necesitas hacernos alguna consulta o recibir una cotizaci\u00f3n, rellena el siguiente formulario. Nuestro equipo estar\u00e1 encantado de responder (habitualmente en 24-48h).<\/div>\n<\/div>\n<div class=\"_form_element _x57136782 _inline-style \"><label for=\"firstname\" class=\"_form-label\"> Nombre<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"_field-wrapper\"><input type=\"text\" id=\"firstname\" name=\"firstname\" placeholder=\"Escribe aqu\u00ed tu nombre\" required=\"\" \/><\/div>\n<\/div>\n<div class=\"_form_element _x88535341 _inline-style \"><label for=\"lastname\" class=\"_form-label\"> Apellido<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"_field-wrapper\"><input type=\"text\" id=\"lastname\" name=\"lastname\" placeholder=\"Escribe aqu\u00ed tu apellido\" required=\"\" \/><\/div>\n<\/div>\n<div class=\"_form_element _x00406724 _inline-style \"><label for=\"field[5]\" class=\"_form-label\"> Pa\u00eds<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"_field-wrapper\"><input type=\"text\" id=\"field[5]\" name=\"field[5]\" value=\"\" placeholder=\"Escribe aqu\u00ed tu pa\u00eds\" required=\"\" \/><\/div>\n<\/div>\n<div class=\"_form_element _x39402032 _inline-style \"><label for=\"email\" class=\"_form-label\"> Email<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"_field-wrapper\"><input type=\"text\" id=\"email\" name=\"email\" placeholder=\"Escribe aqu\u00ed tu email\" required=\"\" \/><\/div>\n<\/div>\n<div class=\"_form_element _x05000583 _inline-style \"><label for=\"field[1]\" class=\"_form-label\"> Instituci\u00f3n<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"_field-wrapper\"><input type=\"text\" id=\"field[1]\" name=\"field[1]\" value=\"\" placeholder=\"Escribe aqu\u00ed tu instituci\u00f3n\" required=\"\" \/><\/div>\n<\/div>\n<div class=\"_form_element _x86780241 _inline-style \"><label for=\"field[41]\" class=\"_form-label\"> Mensaje <\/label><\/p>\n<div class=\"_field-wrapper\"><textarea id=\"field[41]\" name=\"field[41]\" placeholder=\"Escribe aqu\u00ed tu mensaje\" style=\"height: 98px;\"><\/textarea><\/div>\n<\/div>\n<div class=\"_form_element _x79910526 _inline-style \"><label for=\"g-recaptcha-response\" class=\"_form-label\"> Verifica que no eres un robot<span class=\"field-required\"> * <\/span> <\/label><\/p>\n<div class=\"g-recaptcha\" data-sitekey=\"6LcwIw8TAAAAACP1ysM08EhCgzd6q5JAOUR1a0Go\"><\/div>\n<\/div>\n<div class=\"_form_element _x80598199 _inline-style _clear\">\n<div class=\"_html-code\">Al enviar el formulario, declaro que acepto los t\u00e9rminos y condiciones descritos en la Pol\u00edtica de Privacidad (Immunostep siempre respetar\u00e1 tu privacidad).<\/div>\n<\/div>\n<div class=\"_button-wrapper _inline-style\"><button id=\"_form_172_submit\" class=\"_submit\" type=\"submit\"> Enviar <\/button><\/div>\n<div class=\"_clear-element\"><\/div>\n<\/div>\n<div class=\"_form-thank-you\" style=\"display: none;\"><\/div>\n<\/form>\n<\/div>\n<p><script>\nwindow.cfields = {\"5\":\"country\",\"1\":\"institution\",\"41\":\"message_form\"};\nwindow._show_thank_you = function(id, message, trackcmp_url, email) {\n    var form = document.getElementById('_form_' + id + '_'), thank_you = form.querySelector('._form-thank-you');\n    form.querySelector('._form-content').style.display = 'none';\n    thank_you.innerHTML = message;\n    thank_you.style.display = 'block';\n    const vgoAlias = typeof visitorGlobalObjectAlias === 'undefined' ? 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Please try again.\");\n                });\n            } else {\n                _load_script('https:\/\/immunostep91401.activehosted.com\/proc.php?' + serialized + '&jsonp=true', null, true);\n            }\n        }\n        return false;\n    };\n    addEvent(form_to_submit, 'submit', form_submit);\n})();<\/p>\n<p><\/script><\/p>\n<\/div>\n<p><!--more--><br \/>\n<!-- {\"type\":\"layout\",\"children\":[{\"type\":\"section\",\"props\":{\"height\":\"viewport\",\"height_offset_top\":true,\"image\":\"wp-content\\\/uploads\\\/2026\\\/04\\\/Presentacion-de-antigeno3.png\",\"image_effect\":\"fixed\",\"image_position\":\"center-center\",\"image_size\":\"cover\",\"media_overlay\":\"rgba(0, 0, 0, 0.15)\",\"padding_remove_horizontal\":false,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"text_color\":\"light\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"image\",\"props\":{\"image\":\"\",\"image_svg_color\":\"emphasis\",\"image_width\":\"90\",\"margin\":\"default\",\"margin_remove_bottom\":true}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h1>Detecci\\u00f3n de la clonalidad de las c\\u00e9lulas T:<\\\/h1>\",\"margin\":\"default\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"text_color\":\"light\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p>La identificaci\\u00f3n exhaustiva de los subconjuntos de c\\u00e9lulas T permite realizar diagn\\u00f3sticos de c\\u00e1ncer m\\u00e1s precisos.<\\\/p>\\n\n\n<p>Para ello, ofrecemos reactivos de alta especificidad y sensibilidad que permiten realizar an\\u00e1lisis eficaces y seguros mediante citometr\\u00eda de flujo.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><\\\/p>\",\"margin\":\"default\"}},{\"type\":\"button\",\"props\":{\"grid_column_gap\":\"small\",\"grid_row_gap\":\"small\",\"margin\":\"default\"},\"children\":[{\"type\":\"button_item\",\"props\":{\"button_style\":\"secondary\",\"content\":\"Descubre c\\u00f3mo funciona\",\"icon_align\":\"left\",\"link\":\"#findout\"}}]}]}],\"props\":{\"layout\":\"1-2,1-2\"}}]},{\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p><\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\">El complejo <b>CD3-TCR<\\\/b> interviene en el desarrollo y la activaci\\u00f3n de los linfocitos T.<\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\">Est\\u00e1 formado por la <b>mol\\u00e9cula dim\\u00e9rica TCR<\\\/b> (receptor de c\\u00e9lulas T) y la <b>mol\\u00e9cula hexam\\u00e9rica CD3.<\\\/b><\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\"><b>CD3<\\\/b> est\\u00e1 formado por cuatro cadenas diferentes, \\u03b3, \\u03b4, \\u03b5 y \\u03b6, que se combinan para formar 3 d\\u00edmeros: un <b>homod\\u00edmero \\u03b6\\\/\\u03b6<\\\/b> y <b>dos heterod\\u00edmeros<\\\/b>, <b>\\u03b3\\\/\\u03b5 y \\u03b4\\\/\\u03b5.<\\\/b><\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\">Las cadenas \\u03b3, \\u03b4 y \\u03b5 tienen una regi\\u00f3n <b>ITAM<\\\/b> (motivo inmunoestimulador basado en tirosina), y la cadena \\u03b6 tiene tres ITAM; esta regi\\u00f3n interviene en la activaci\\u00f3n celular. El complejo CD3 act\\u00faa como correceptor del TCR cuando reconoce un ant\\u00edgeno y participa en la se\\u00f1alizaci\\u00f3n interna de los linfocitos.<\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\">El TCR puede estar formado por una <b>cadena \\u03b1<\\\/b> y una <b>cadena \\u03b2 (TCR \\u03b1\\\/\\u03b2)<\\\/b> o por una cadena \\u03b3 y una cadena \\u03b4 (TCR \\u03b3\\\/\\u03b4), siendo la mayor\\u00eda de los linfocitos T de la sangre perif\\u00e9rica del tipo \\u03b1\\\/\\u03b2 y los del tipo \\u03b3\\\/\\u03b4 m\\u00e1s abundantes en el tejido epitelial. Ambas cadenas tienen una regi\\u00f3n constante (C) y una regi\\u00f3n variable (V), correspondiendo esta \\u00faltima al sitio de uni\\u00f3n al ant\\u00edgeno que recibe el p\\u00e9ptido presentado por el <b>MHC (Complejo Mayor de Histocompatibilidad)<\\\/b> de las c\\u00e9lulas presentadoras de ant\\u00edgenos.<\\\/p>\\n\n\n<p style=\\\"text-align: center;\\\">En el caso del <b>TCR \\u03b1\\\/\\u03b2,<\\\/b> la regi\\u00f3n constante de la cadena \\u03b2 presenta dos tipos, \\u03b21 o \\u03b22, por lo que se pueden distinguir dos poblaciones de <b>linfocitos T \\u03b1\\\/\\u03b2: TCR C\\u03b21 (o TRBC1) y TCR C\\u03b22 (o TRBC2).<\\\/b><\\\/p>\",\"margin\":\"default\"}}]}]}],\"name\":\"Results 1\"},{\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"padding_remove_bottom\":true,\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h1>Complejo CD3-TCR<\\\/h1>\",\"margin\":\"default\",\"margin_remove_bottom\":true}},{\"type\":\"popover\",\"props\":{\"background_image\":\"wp-content\\\/uploads\\\/2026\\\/04\\\/FINAL-FLYER-7.png\",\"card_style\":\"default\",\"drop_mode\":\"hover\",\"drop_position\":\"top-center\",\"icon\":\"plus\",\"image_card_padding\":true,\"image_svg_color\":\"emphasis\",\"link_style\":\"default\",\"link_text\":\"Read more\",\"margin\":\"default\",\"margin_remove_bottom\":true,\"margin_remove_top\":true,\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"show_content\":true,\"show_image\":true,\"show_link\":true,\"show_meta\":true,\"show_title\":true,\"title_element\":\"h3\",\"title_hover_style\":\"reset\"},\"children\":[{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>Adem\\u00e1s de su papel en la activaci\\u00f3n, interviene en el correcto <b>ensamblaje de los receptores de c\\u00e9lulas T (TCR)<\\\/b> y en su expresi\\u00f3n extracelular a trav\\u00e9s de la <b>v\\u00eda de activaci\\u00f3n de la ERK (quinasa regulada por se\\u00f1ales extracelulares)<\\\/b>, lo cual es importante para la selecci\\u00f3n positiva de los timocitos.<\\\/p>\",\"position_x\":\"29\",\"position_y\":\"44\",\"title\":\"CD3\\u03b4\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>Desempe\\u00f1a un papel en la regulaci\\u00f3n de la <b>expresi\\u00f3n del TCR<\\\/b> y en la selecci\\u00f3n negativa t\\u00edmica, y es un componente clave de la se\\u00f1alizaci\\u00f3n celular.<\\\/p>\",\"position_x\":\"69\",\"position_y\":\"45\",\"title\":\"CD3\\u03b5\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>Desempe\\u00f1a un papel en la activaci\\u00f3n celular, en el ensamblaje inicial del TCR y en la regulaci\\u00f3n de su expresi\\u00f3n en la superficie celular <b>a trav\\u00e9s de la v\\u00eda de activaci\\u00f3n de la ERK (quinasa regulada por se\\u00f1ales extracelulares)<\\\/b>.<\\\/p>\",\"position_x\":\"62\",\"position_y\":\"45\",\"title\":\"CD3\\u03b3\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p><b>El d\\u00edmero \\u03b6\\u03b6, CD247,<\\\/b> tiene tres ITAM por cadena y participa tanto en la activaci\\u00f3n celular como en la diferenciaci\\u00f3n intrat\\u00edmica.<\\\/p>\",\"position_x\":\"38\",\"position_y\":\"85\",\"title\":\"CD3\\u03b6\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>V\\u00edas de se\\u00f1alizaci\\u00f3n celular que, mediante la fosforilaci\\u00f3n por parte de tirosina quinasas espec\\u00edficas, permiten la <b>activaci\\u00f3n celular<\\\/b>.<\\\/p>\",\"position_x\":\"69\",\"position_y\":\"78\",\"title\":\"ITAM (Immunoreceptor Tyrosine-based Activation Motif)\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>Una mol\\u00e9cula esencial para el <b>ensamblaje y la regulaci\\u00f3n del TCR<\\\/b> y para la <b>activaci\\u00f3n de los linfocitos T<\\\/b>. Est\\u00e1 formada por seis cadenas: \\u03b3, \\u03b4, \\u03b5 (dos cadenas) y \\u03b6 (dos cadenas).<\\\/p>\",\"position_x\":\"56\",\"position_y\":\"97\",\"title\":\"CD3\"}},{\"type\":\"popover_item\",\"props\":{\"content\":\"\n\n<p>Posee sitios de uni\\u00f3n espec\\u00edficos en su regi\\u00f3n variable para los ant\\u00edgenos presentados por las c\\u00e9lulas a trav\\u00e9s de la <b>interacci\\u00f3n MHC-TCR,<\\\/b> lo que permite el reconocimiento espec\\u00edfico y la activaci\\u00f3n funcional de la c\\u00e9lula para desencadenar una respuesta inmunitaria. Est\\u00e1 compuesto por una <b>cadena \\u03b1<\\\/b> y una <b>cadena \\u03b2;<\\\/b> esta \\u00faltima puede clasificarse como \\u03b21 o \\u03b22.<\\\/p>\",\"position_x\":\"55\",\"position_y\":\"4\",\"title\":\"TCR (T Cell Receptor)\"}}]},{\"type\":\"divider\",\"props\":{\"divider_element\":\"hr\",\"margin\":\"xlarge\",\"position\":\"relative\"}}]}]}],\"name\":\"The kit includes\"},{\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"props\":{\"layout\":\"2-3,1-3\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"2-3\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h5 class=\\\"uk-heading-bullet uk-text-center\\\" data-id=\\\"page#6-0-1-0\\\">CONTEXTO\\\/RELEVANCIA CL\\u00cdNICA<\\\/h5>\",\"margin\":\"default\",\"text_align\":\"left\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p>El diagn\\u00f3stico de las neoplasias de c\\u00e9lulas T se ha beneficiado enormemente del desarrollo de anticuerpos dirigidos contra la regi\\u00f3n constante de la cadena \\u03b2 (C\\u03b2) de la mol\\u00e9cula del receptor de c\\u00e9lulas T (TCR), lo que ha permitido analizar la distribuci\\u00f3n de las poblaciones C<i>\\u03b2<\\\/i>1 y C<i>\\u03b22<\\\/i> e identificar anomal\\u00edas que puedan indicar una enfermedad.<\\\/p>\",\"margin\":\"default\"}},{\"type\":\"image\",\"props\":{\"image\":\"wp-content\\\/uploads\\\/2026\\\/04\\\/TCR-C\\u03b221.png\",\"image_alt\":\"TCR C\\u03b22\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"text\",\"props\":{\"block_align\":\"center\",\"column_breakpoint\":\"m\",\"content\":\"\n\n<p><\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p>Este m\\u00e9todo de detecci\\u00f3n es similar al modelo de diagn\\u00f3stico de la neoplasia de c\\u00e9lulas B, que se basa en la restricci\\u00f3n de las cadenas ligeras de inmunoglobulina de membrana a las cadenas kappa (<i>\\u03ba<\\\/i>) o lambda (<i>\\u03bb<\\\/i>).<\\\/p>\\n\n\n<p>El uso simult\\u00e1neo de ambos anticuerpos (TCR C<i>\\u03b2<\\\/i>1 y TCR C<i>\\u03b2<\\\/i>2) garantiza la separaci\\u00f3n correcta y espec\\u00edfica de las poblaciones para identificar con precisi\\u00f3n la relaci\\u00f3n entre ambas.<\\\/p>\\n\n\n<p>De este modo, es posible detectar si existe clonalidad, es decir, una distribuci\\u00f3n completa o abrumadoramente predominante hacia un \\u00fanico tipo de cadena <i>\\u03b2<\\\/i>, lo que podr\\u00eda ser indicativo de una neoplasia de c\\u00e9lulas T.<\\\/p>\\n\n\n<p><\\\/p>\",\"margin\":\"default\",\"maxwidth\":\"large\",\"position\":\"relative\",\"position_bottom\":\"20\"}},{\"type\":\"button\",\"props\":{\"grid_column_gap\":\"small\",\"grid_row_gap\":\"small\",\"margin\":\"default\"},\"children\":[{\"type\":\"button_item\",\"props\":{\"button_style\":\"default\",\"content\":\"CONTACTA CON NUESTROS EXPERTOS\",\"icon_align\":\"left\",\"link\":\"https:\\\/\\\/immunostep.com\\\/es\\\/immunostep\\\/contacto\\\/\"}}]}]}]}],\"name\":\"V\\u00eddeos\"},{\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h5 class=\\\"uk-heading-bullet uk-text-center\\\" data-id=\\\"page#6-0-1-0\\\" style=\\\"text-align: center;\\\">AN\\u00c1LISIS ESTRAT\\u00c9GICO<\\\/h5>\",\"margin\":\"default\"}},{\"type\":\"image\",\"props\":{\"image\":\"wp-content\\\/uploads\\\/2026\\\/04\\\/TCR-Landing.pptx.jpg\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\",\"position\":\"relative\",\"position_left\":\"90\",\"text_align\":\"center\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h6 style=\\\"text-align: center;\\\">Ejemplo de una estrategia de an\\u00e1lisis para un donante sano muestra de sangre perif\\u00e9rica; se ha detectado clonalidad de las c\\u00e9lulas T colaboradoras (CD4+) TCR C\\u03b22).<\\\/h6>\\n\n\n<p>En el caso de los linfocitos T, la poblaci\\u00f3n espec\\u00edfica se identifica mediante <b>anti-CD3<\\\/b> y las subpoblaciones se analizan seg\\u00fan pertenezcan al <b>TCR C<i>\\u03b2<\\\/i>1<\\\/b> o al <b>TCR C<i>\\u03b2<\\\/i>2<\\\/b>. Es recomendable realizar un inmunofenotipado m\\u00e1s preciso, separando primero las poblaciones de TCR <i>\\u03b1\\\/\\u03b2<\\\/i> y TCR <i>\\u03b3\\\/\\u03b4<\\\/i>, para identificar posteriormente las subpoblaciones de TCR <i>\\u03b1\\\/\\u03b2<\\\/i>: <b>CD4+\\\/CD8-<\\\/b> (c\\u00e9lulas T colaboradoras o Th), <b>CD4-\\\/CD8+<\\\/b> (c\\u00e9lulas T citot\\u00f3xicas o Tc), <b>CD4-\\\/CD8-<\\\/b> (c\\u00e9lulas T doblemente negativas o DN) y <b>CD4+\\\/CD8+<\\\/b> (c\\u00e9lulas T doblemente positivas o DP).<\\\/p>\\n\n\n<p><b>Los linfocitos T TCR <i>\\u03b3\\\/\\u03b4<\\\/i><\\\/b> identificados tambi\\u00e9n pueden analizarse junto con los dem\\u00e1s marcadores auxiliares.<\\\/p>\\n\n\n<p>El uso de reactivos auxiliares permite un diagn\\u00f3stico m\\u00e1s fiable y preciso, ya que proporciona informaci\\u00f3n detallada sobre todas las poblaciones posibles y su cuantificaci\\u00f3n exacta. Es adecuado utilizar anticuerpos <b>TCR <i>\\u03b1\\\/\\u03b2<\\\/i>, TCR <i>\\u03b3\\\/\\u03b4<\\\/i>, CD4 y CD8<\\\/b> en combinaci\\u00f3n con <b>TCR C<i>\\u03b2<\\\/i>1 y C<i>\\u03b2<\\\/i>2<\\\/b>, y otros marcadores de poblaci\\u00f3n (tanto espec\\u00edficos de c\\u00e9lulas T como no espec\\u00edficos) y marcadores de maduraci\\u00f3n para detectar una expresi\\u00f3n an\\u00f3mala o ausente, lo que proporciona una interpretaci\\u00f3n m\\u00e1s completa y sensible.<\\\/p>\",\"margin\":\"default\"}}]}]}]},{\"type\":\"section\",\"props\":{\"id\":\"Resources\",\"image_position\":\"center-center\",\"padding_remove_bottom\":true,\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"large\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"3-5\"},\"children\":[{\"type\":\"headline\",\"props\":{\"content\":\"REFERENCIAS DE PRODUCTO\",\"text_align\":\"center\",\"title_decoration\":\"bullet\",\"title_element\":\"h5\"}},{\"type\":\"table\",\"props\":{\"block_align\":\"center\",\"image_svg_color\":\"emphasis\",\"link_size\":\"small\",\"link_style\":\"secondary\",\"link_target\":false,\"link_text\":\"More info\",\"maxwidth\":\"2xlarge\",\"meta_color\":\"primary\",\"meta_style\":\"text-meta\",\"show_content\":true,\"show_image\":true,\"show_link\":true,\"show_meta\":true,\"show_title\":true,\"table_head_content\":\"Description\",\"table_head_meta\":\"Reference\",\"table_head_title\":\"Product name\",\"table_hover\":true,\"table_justify\":false,\"table_order\":\"5\",\"table_responsive\":\"responsive\",\"table_style\":\"divider\",\"table_vertical_align\":true,\"table_width_meta\":\"\",\"table_width_title\":\"\",\"text_align\":\"center\"},\"children\":[{\"type\":\"table_item\",\"props\":{\"content\":\"\n\n<p>El anticuerpo monoclonal JOVI.1 reconoce un ep\\u00edtopo com\\u00fan a una gran proporci\\u00f3n de linfocitos T CD4+ o CD8+ humanos que expresan la cadena beta del receptor de c\\u00e9lulas T (TCR\\u03b2)<\\\/p>\",\"link\":\"https:\\\/\\\/immunostep.com\\\/product\\\/tcr-cbeta1\\\/?v=12470fe406d4\",\"link_text\":\"Ver en la tienda\",\"meta\":\"PJOVI\",\"title\":\"TCR CBeta 1\"}},{\"type\":\"table_item\",\"props\":{\"content\":\"\n\n<p>El anticuerpo monoclonal recombinante SAM.2.rMAb reconoce espec\\u00edficamente la regi\\u00f3n constante C\\u03b22 del TCR<\\\/p>\",\"link\":\"https:\\\/\\\/immunostep.com\\\/product\\\/anti-human-t-cr-c%ce%b2-2-sam-2-rmab\\\/?v=12470fe406d4\",\"link_text\":\"Ver en la tienda\",\"meta\":\"TCRCB2PE\",\"title\":\"TCR CBeta 2\"}},{\"type\":\"table_item\",\"props\":{\"content\":\"\n\n<p>Este anticuerpo se dirige contra un determinante de la regi\\u00f3n constante presente en la superficie de todos los linfocitos T que expresan el TCR \\u03b1\\\/\\u03b2 1<\\\/p>\",\"link\":\"https:\\\/\\\/immunostep.com\\\/product\\\/anti-human-%ce%b1%ce%b2-t-cell-receptor-ip26\\\/?v=12470fe406d4\",\"link_text\":\"Ver en la tienda\",\"meta\":\"TCRABPE\",\"title\":\"TCRa\\\/b\"}},{\"type\":\"table_item\",\"props\":{\"content\":\"\n\n<p>El TCR \\u03b3\\\/\\u03b4 es una glicoprote\\u00edna heterodim\\u00e9rica que se une de forma no covalente al ant\\u00edgeno CD3 1<\\\/p>\",\"link\":\"https:\\\/\\\/immunostep.com\\\/product\\\/tcrg-d\\\/?v=12470fe406d4\",\"link_text\":\"Ver en la tienda\",\"meta\":\"TCRGD\",\"title\":\"TCRg\\\/d\"}}],\"modified\":\"2022-03-23T08:31:39.569Z\",\"name\":\"Tabla References Cell analysis\"}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"2-5\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h5 class=\\\"uk-heading-bullet uk-text-center\\\" data-id=\\\"page#6-0-1-0\\\">RECURSOS Y MATERIALES<\\\/h5>\",\"margin\":\"default\"}},{\"type\":\"list\",\"props\":{\"block_align\":\"center\",\"column_breakpoint\":\"m\",\"icon\":\"triangle-right\",\"icon_width\":\"30\",\"image_align\":\"left\",\"image_svg_color\":\"emphasis\",\"image_vertical_align\":true,\"list_element\":\"ul\",\"list_horizontal_separator\":\", \",\"list_style\":\"striped\",\"list_type\":\"vertical\",\"maxwidth\":\"2xlarge\",\"show_image\":true,\"show_link\":true,\"text_align\":\"left\"},\"children\":[{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Technical Data Sheet (TDS) (RUO)\\u2013 (English)- TCR Beta 1<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/TDS_JOVI_JOVI-1_RUO_2.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Technical Data Sheet (TDS) (RUO)\\u2013(EN)- TCR Beta 2<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/TDS-ANTI-HUMAN-T-CELL-RECEPTOR-SAM-2-rMAbpdf-1.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Technical Data Sheet (TDS) \\u2013 (English)-TCRa\\\/b<\\\/p>\\n\n\n<p><a href=\\\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Anti-Human-\\u03b1\\u03b2-T-Cell-Receptor-IP26-1.pdf?v=12470fe406d4\\\"><strong><\\\/strong><\\\/a><\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Anti-Human-%CE%B1%CE%B2-T-Cell-Receptor-IP26-1.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Technical Data Sheet (TDS) (RUO)\\u2013(English)- TCRg\\\/d<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/TDS_TCRg-d-11F2-v1.docx?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>TDS-CE-Ficha T\\u00e9cnica- TCR Beta 1<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/TDS_TCR-CBeta1-FITC-Clon-JOVI.1-Espanol.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Technical note \\u2013 (English)<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/TECHNICAL-NOTE-TCRCB2-2.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Safety Sheet (MSDS) \\u2013 (English)<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/MSDS_ANTIBODIES_EN_RUO.pdf?v=12470fe406d4\",\"link_target\":true}},{\"type\":\"list_item\",\"props\":{\"content\":\"\n\n<p>Flyer (English)<\\\/p>\",\"icon\":\"file-pdf\",\"link\":\"https:\\\/\\\/immunostep.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/FLYER-BETA-FINAL.pdf?v=12470fe406d4\",\"link_target\":true}}],\"modified\":\"2022-03-23T08:31:57.391Z\",\"name\":\"Resources-Cellanalysis\"}]}],\"props\":{\"layout\":\"3-5,2-5\"}},{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"divider\",\"props\":{\"divider_element\":\"hr\"}}]}]}],\"name\":\"References and resources\"},{\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"padding_remove_bottom\":true,\"padding_remove_top\":false,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<h1 class=\\\"uk-heading-bullet uk-width-2xlarge\\\" data-id=\\\"page#0-0-0-0\\\">Preguntas Frecuentes (FAQs)<\\\/h1>\",\"margin\":\"default\",\"margin_remove_bottom\":false}},{\"type\":\"accordion\",\"props\":{\"collapsible\":true,\"content_column_breakpoint\":\"m\",\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"default\",\"link_text\":\"Read more\",\"margin_remove_top\":false,\"show_image\":true,\"show_link\":true},\"children\":[{\"type\":\"accordion_item\",\"props\":{\"content\":\"\n\n<p><b>S\\u00ed,<\\\/b> pero se recomienda utilizar los clones UCHT1 o SK7 para un mejor reconocimiento de la <b>mol\\u00e9cula TCR.<\\\/b> Otros clones anti-CD3, como el 33-2A3, interfieren de forma m\\u00e1s significativa en la uni\\u00f3n de los anticuerpos anti-TCR y pueden complicar el an\\u00e1lisis.<\\\/p>\",\"title\":\"\\u00bfSe puede utilizar cualquier anticuerpo secundario contra CD3?\"}},{\"type\":\"accordion_item\",\"props\":{\"content\":\"\n\n<p><b>No es estrictamente necesario,<\\\/b> pero mejora la precisi\\u00f3n del diagn\\u00f3stico al garantizar una separaci\\u00f3n completa entre poblaciones mutuamente excluyentes.<\\\/p>\",\"title\":\"\\u00bfEs necesario utilizar ambos anticuerpos, TCR C\\u03b21 y TCR C\\u03b22, para identificar las poblaciones?\"}},{\"type\":\"accordion_item\",\"props\":{\"content\":\"\n\n<p>No, el n\\u00famero de leucocitos no se ve afectado y <strong>se recomienda lisar todas las muestras<\\\/strong>, de acuerdo con las <strong>directrices de EUROFLOW<\\\/strong>, incluyendo aquellas muestras de LCR en las que no haya contaminaci\\u00f3n visible con RBCs. En este sentido, no se observan diferencias significativas entre el paso de lisis (FACS Lysing) y el paso de lavado con PBS, siendo la manipulaci\\u00f3n de la muestra, y en particular la decantaci\\u00f3n del sobrenadante, y no la lisis, la principal causa de p\\u00e9rdida celular, por lo que se recomienda aspirar y no decantar los sobrenadantes tras los pasos de centrifugaci\\u00f3n.<\\\/p>\",\"title\":\"\\u00bfPuede el procedimiento de lisis de los RBCs afectar al n\\u00famero de leucocitos presentes en la muestra?\"}}]}]}]},{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"divider\",\"props\":{\"divider_element\":\"hr\"}}]}]}],\"name\":\"FAQs\"},{\"type\":\"section\",\"props\":{\"id\":\"contactAC\",\"image_position\":\"center-center\",\"padding_remove_top\":true,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"default\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"text\",\"props\":{\"block_align\":\"center\",\"column_breakpoint\":\"m\",\"content\":\"\n\n<p>\n\n<style>@import url(https:\\\/\\\/fonts.bunny.net\\\/css?family=sans-serif:400);<\\\/style> \n\n<style>\\n#_form_172_{font-size:14px;line-height:1.6;font-family:arial, helvetica, 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._form-subscriptions-unsubscribe-all-description{line-height:normal;margin-top:-2px}<\\\/style><\\\/p>\\n\n\n<div style=\\\"text-align: center;\\\">\n\n<form method=\\\"POST\\\" action=\\\"https:\\\/\\\/immunostep91401.activehosted.com\\\/proc.php\\\" id=\\\"_form_172_\\\" class=\\\"_form _form_172 _inline-form _inline-style _dark\\\" novalidate=\\\"\\\" data-styles-version=\\\"5\\\"><input type=\\\"hidden\\\" name=\\\"u\\\" value=\\\"172\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"f\\\" value=\\\"172\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"s\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"c\\\" value=\\\"0\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"m\\\" value=\\\"0\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"act\\\" value=\\\"sub\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"v\\\" value=\\\"2\\\" \\\/> <input type=\\\"hidden\\\" name=\\\"or\\\" value=\\\"78def15b-053a-40b8-b9b1-f3725b624cd7\\\" \\\/>\\n\n\n<div class=\\\"_form-content\\\">\\n\n\n<div class=\\\"_form_element _x31702129 _inline-style _clear\\\">\\n\n\n<h2 class=\\\"_form-title\\\">\\u00bfAlguna pregunta sobre nuestro complejo CD3?<\\\/h2>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x92707266 _inline-style _clear\\\">\\n\n\n<div class=\\\"_html-code\\\">Si necesitas hacernos alguna consulta o recibir una cotizaci\\u00f3n, rellena el siguiente formulario. Nuestro equipo estar\\u00e1 encantado de responder (habitualmente en 24-48h).<\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x57136782 _inline-style \\\"><label for=\\\"firstname\\\" class=\\\"_form-label\\\"> Nombre<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><input type=\\\"text\\\" id=\\\"firstname\\\" name=\\\"firstname\\\" placeholder=\\\"Escribe aqu\\u00ed tu nombre\\\" required=\\\"\\\" \\\/><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x88535341 _inline-style \\\"><label for=\\\"lastname\\\" class=\\\"_form-label\\\"> Apellido<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><input type=\\\"text\\\" id=\\\"lastname\\\" name=\\\"lastname\\\" placeholder=\\\"Escribe aqu\\u00ed tu apellido\\\" required=\\\"\\\" \\\/><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x00406724 _inline-style \\\"><label for=\\\"field[5]\\\" class=\\\"_form-label\\\"> Pa\\u00eds<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><input type=\\\"text\\\" id=\\\"field[5]\\\" name=\\\"field[5]\\\" value=\\\"\\\" placeholder=\\\"Escribe aqu\\u00ed tu pa\\u00eds\\\" required=\\\"\\\" \\\/><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x39402032 _inline-style \\\"><label for=\\\"email\\\" class=\\\"_form-label\\\"> Email<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><input type=\\\"text\\\" id=\\\"email\\\" name=\\\"email\\\" placeholder=\\\"Escribe aqu\\u00ed tu email\\\" required=\\\"\\\" \\\/><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x05000583 _inline-style \\\"><label for=\\\"field[1]\\\" class=\\\"_form-label\\\"> Instituci\\u00f3n<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><input type=\\\"text\\\" id=\\\"field[1]\\\" name=\\\"field[1]\\\" value=\\\"\\\" placeholder=\\\"Escribe aqu\\u00ed tu instituci\\u00f3n\\\" required=\\\"\\\" \\\/><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x86780241 _inline-style \\\"><label for=\\\"field[41]\\\" class=\\\"_form-label\\\"> Mensaje <\\\/label>\\n\n\n<div class=\\\"_field-wrapper\\\"><textarea id=\\\"field[41]\\\" name=\\\"field[41]\\\" placeholder=\\\"Escribe aqu\\u00ed tu mensaje\\\" style=\\\"height: 98px;\\\"><\\\/textarea><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x79910526 _inline-style \\\"><label for=\\\"g-recaptcha-response\\\" class=\\\"_form-label\\\"> Verifica que no eres un robot<span class=\\\"field-required\\\"> * <\\\/span> <\\\/label>\\n\n\n<div class=\\\"g-recaptcha\\\" data-sitekey=\\\"6LcwIw8TAAAAACP1ysM08EhCgzd6q5JAOUR1a0Go\\\"><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form_element _x80598199 _inline-style _clear\\\">\\n\n\n<div class=\\\"_html-code\\\">Al enviar el formulario, declaro que acepto los t\\u00e9rminos y condiciones descritos en la Pol\\u00edtica de Privacidad (Immunostep siempre respetar\\u00e1 tu privacidad).<\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_button-wrapper _inline-style\\\"><button id=\\\"_form_172_submit\\\" class=\\\"_submit\\\" type=\\\"submit\\\"> Enviar <\\\/button><\\\/div>\\n\n\n<div class=\\\"_clear-element\\\"><\\\/div>\\n<\\\/div>\\n\n\n<div class=\\\"_form-thank-you\\\" style=\\\"display: none;\\\"><\\\/div>\\n<\\\/form><\\\/div>\\n\n\n<p><script>\\nwindow.cfields = {\\\"5\\\":\\\"country\\\",\\\"1\\\":\\\"institution\\\",\\\"41\\\":\\\"message_form\\\"};\\nwindow._show_thank_you = function(id, message, trackcmp_url, email) {\\n    var form = document.getElementById('_form_' + id + '_'), thank_you = form.querySelector('._form-thank-you');\\n    form.querySelector('._form-content').style.display = 'none';\\n    thank_you.innerHTML = message;\\n    thank_you.style.display = 'block';\\n    const vgoAlias = typeof visitorGlobalObjectAlias === 'undefined' ? 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Please shorten your responses and try again.\\\");\\n            } else {\\n                _show_error(\\\"172\\\", \\\"Sorry, your submission failed. Please try again.\\\");\\n            }\\n            submitButton.disabled = false;\\n            submitButton.classList.remove('processing');\\n        }\\n    }\\n\\n    head.appendChild(script);\\n};\\n(function() {\\n    var iti;\\n    if (window.location.search.search(\\\"excludeform\\\") !== -1) return false;\\n    var getCookie = function(name) {\\n        var match = document.cookie.match(new RegExp('(^|; )' + name + '=([^;]+)'));\\n        return match ? match[2] : localStorage.getItem(name);\\n    }\\n    var setCookie = function(name, value) {\\n        var now = new Date();\\n        var time = now.getTime();\\n        var expireTime = time + 1000 * 60 * 60 * 24 * 365;\\n        now.setTime(expireTime);\\n        document.cookie = name + '=' + value + '; expires=' + now + ';path=\\\/; Secure; SameSite=Lax;';\\n        localStorage.setItem(name, value);\\n    }\\n    var addEvent = function(element, event, func) {\\n        if (element.addEventListener) {\\n            element.addEventListener(event, func);\\n        } else {\\n            var oldFunc = element['on' + event];\\n            element['on' + event] = function() {\\n                oldFunc.apply(this, arguments);\\n                func.apply(this, arguments);\\n            };\\n        }\\n    }\\n    var _removed = false;\\n        var form_to_submit = document.getElementById('_form_172_');\\n    var allInputs = form_to_submit.querySelectorAll('input, select, textarea'), tooltips = [], submitted = false;\\n\\n    var getUrlParam = function(name) {\\n        if (name.toLowerCase() !== 'email') {\\n            var params = new URLSearchParams(window.location.search);\\n            return params.get(name) || false;\\n        }\\n        \\\/\\\/ email is a special case because a plus is valid in the email address\\n        var qString = window.location.search;\\n        if (!qString) {\\n            return false;\\n        }\\n        var parameters = qString.substr(1).split('&');\\n        for (var i = 0; i < parameters.length; i++) {\\n            var parameter = parameters[i].split('=');\\n            if (parameter[0].toLowerCase() === 'email') {\\n                return parameter[1] === undefined ? true : decodeURIComponent(parameter[1]);\\n            }\\n        }\\n        return false;\\n    };\\n\\n    var acctDateFormat = \\\"%d\\\/%m\\\/%Y\\\";\\n    var getNormalizedDate = function(date, acctFormat) {\\n        var decodedDate = decodeURIComponent(date);\\n        if (acctFormat && acctFormat.match(\\\/(%d|%e).*%m\\\/gi) !== null) {\\n            return decodedDate.replace(\\\/(\\\\d{2}).*(\\\\d{2}).*(\\\\d{4})\\\/g, '$3-$2-$1');\\n        } else if (Date.parse(decodedDate)) {\\n            var dateObj = new Date(decodedDate);\\n            var year = dateObj.getFullYear();\\n            var month = dateObj.getMonth() + 1;\\n            var day = dateObj.getDate();\\n            return `${year}-${month < 10 ? `0${month}` : month}-${day < 10 ? `0${day}` : day}`;\\n        }\\n        return false;\\n    };\\n\\n    var getNormalizedTime = function(time) {\\n        var hour, minutes;\\n        var decodedTime = decodeURIComponent(time);\\n        var timeParts = Array.from(decodedTime.matchAll(\\\/(\\\\d{1,2}):(\\\\d{1,2})\\\\W*([AaPp][Mm])?\\\/gm))[0];\\n        if (timeParts[3]) { \\\/\\\/ 12 hour format\\n            var isPM = timeParts[3].toLowerCase() === 'pm';\\n            if (isPM) {\\n                hour = parseInt(timeParts[1]) === 12 ? 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Para ello, ofrecemos reactivos de alta especificidad y sensibilidad que permiten realizar an\u00e1lisis eficaces y seguros mediante citometr\u00eda de flujo. Descubre c\u00f3mo funciona El complejo CD3-TCR interviene en el desarrollo y [&hellip;]<\/p>\n","protected":false},"author":225,"featured_media":39645,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-39587","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>COMPLEJO CD3 | Immunostep Biotech<\/title>\n<meta name=\"description\" content=\"complejo-cd3El complejo CD3-TCR interviene en el desarrollo y la activaci\u00f3n de las c\u00e9lulas T. 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