[{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"This antibody reacts with the C3d antigen, a fragment derived from the cleavage of complement component C3. The C3d fragment remains covalently bound to the surface of target cells or pathogens following complement activation, serving as an important marker for immune adherence and clearance. The mouse monoclonal antibody BGRL11 specifically recognizes this human complement fragment C3d. The antigen is a key physiological ligand for complement receptor 2 (CR2\/CD21), facilitating the bridging of innate and adaptive immunity by enhancing B-cell activation and antibody production.","id":40347,"price":656,"purchasable":true,"regular_price":656,"short_description":"This antibody reacts with the C3d antigen, a fragment derived from the cleavage of complement component C3. The C3d fragment remains covalently bound to the surface of target cells or pathogens following complement activation, serving as an important marker for immune adherence and clearance. The mouse monoclonal antibody BGRL11 specifically recognizes this human complement fragment C3d. The antigen is a key physiological ligand for complement receptor 2 (CR2\/CD21), facilitating the bridging of innate and adaptive immunity by senhancing B-cell activation and antibody production.","sku":"C3DA-100T","status":"publish","slug":"anti-human-cd3d-bgrl11","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2026-06-05T09:29:31Z","title":"Anti-Human CD3d (BGRL11)","link":"https:\/\/immunostep.com\/product\/anti-human-cd3d-bgrl11\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Kits"],"description":"ErythoStepTM EMA is based on the selective reactivity of maleimide groups toward free sulfhydryl (\u2014SH) residues present on proteins. Maleimide reacts specifically with accessible thiol groups under near-physiological conditions, forming a stable and irreversible thioether bond. In intact erythrocytes, the number of exposed surface thiols is limited but detectable, primarily originating from transmembrane proteins such as band 3 (anion exchanger 1, AE1), glycophorins, and other membrane-associated proteins whose cysteine accessibility may vary depending on membrane integrity, oxidative status, and storage conditions. Upon incubation with 5-maleimido-eosin, accessible membrane thiols are covalently labeled, anchoring the eosin fluorophore to the erythrocyte membrane. The eosin moiety is a xanthene-based fluorophore excitable at 488 nm, producing emission in the green-yellow spectrum (~540\u2013570 nm), compatible with standard FITC\/PE detection channels depending on optical configuration. Because the labeling is covalent, fluorescence remains stable and does not redistribute between cells. Alterations in erythrocyte membrane protein composition or organization\u2014such as those described in hereditary spherocytosis (HS)\u2014may result in modified EMA fluorescence intensity patterns. For this reason, EMA labeling is widely used in research protocols supporting the evaluation of erythrocyte membrae disorders.","id":39161,"price":275,"purchasable":true,"regular_price":275,"short_description":"ErythoStepTM EMA is based on the selective reactivity of maleimide groups toward free sulfhydryl (\u2014SH) residues present on proteins.","sku":"EMA-25T","status":"publish","slug":"erythrostep-ema","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["kits"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/03\/DSC_0256-300x200.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2026\/03\/DSC_0256-300x200.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2026-02-24T14:06:32Z","title":"ErythroStep\u2122 EMA","link":"https:\/\/immunostep.com\/product\/erythrostep-ema\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Secondary reagents"],"description":"Biotin is a hapten widely used to label biomolecules due to its high affinity for avidin\/streptavidin systems. The anti-biotin antibody allows sensitive detection of biotinylated molecules as a second-step reagent. Its conjugation with PE provides an intense signal, making it particularly suitable for flow cytometry, immunophenotyping, multicolor panels, and the detection of low-abundance targets using indirect labeling strategies.","id":39100,"price":246,"purchasable":true,"regular_price":246,"short_description":"Biotin is a hapten widely used to label biomolecules due to its high affinity for avidin\/streptavidin systems. The anti-biotin antibody allows sensitive detection of biotinylated molecules as a second-step reagent. Its conjugation with PE provides an intense signal, making it particularly suitable for flow cytometry, immunophenotyping, multicolor panels, and the detection of low-abundance targets using indirect labeling strategies.","sku":"BIOTPE-100UG","status":"publish","slug":"anti-biotin-1d4-c5","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["secondary-reagents"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2026-02-06T10:59:22Z","title":"Anti-Biotin (1D4-C5)","link":"https:\/\/immunostep.com\/product\/anti-biotin-1d4-c5\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"IgD is a minor immunoglobulin expressed on na\u00efve B cells and secreted in mucosal tissues, playing roles in B-cell activation and immune defense. The IA6-2 antibody specifically detects IgD, enabling study of B-cell subsets and related immune functions.","id":39018,"price":175,"purchasable":true,"regular_price":175,"short_description":"IgD is a minor immunoglobulin expressed on na\u00efve B cells and secreted in mucosal tissues, playing roles in B-cell activation and immune defense. The IA6-2 antibody specifically detects IgD, enabling study of B-cell subsets and related immune functions.","sku":"","status":"publish","slug":"anti-human-igd-ia6-2","stock_quantity":null,"tags":[],"type":"variable","stock_status":"instock","df_variants_information":["conjugated"],"df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2026-02-03T10:31:00Z","title":"Anti- Human IgD (IA6-2)","link":"https:\/\/immunostep.com\/product\/anti-human-igd-ia6-2\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"This antibody reacts with the CD7-antigen (3A1-antigen), which is expressed on human T lymphocytes.The monoclonal antibody reacts with the cells of the T lymphocyte linage, with the cells of patients with a Lymphocytic Leukaemia of the T lymphocyte origin, and with the cells of patients with the Sezary Syndrome. Platelets and cells of the B lymphocyte myelocytic and monocytic lineage are found negative.","id":38895,"price":0,"purchasable":true,"regular_price":0,"short_description":"","sku":"","status":"publish","slug":"cd7-4h9","stock_quantity":null,"tags":[],"type":"variable","stock_status":"instock","df_variants_information":["conjugated"],"df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2026-01-23T10:04:57Z","title":"CD7 (4H9)","link":"https:\/\/immunostep.com\/product\/cd7-4h9\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"CD73, also known as ecto-5'- nucleotidase (NT5E), is a 70 kDa glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme that catalyzes the dephosphorylation of extracellular adenosine monophosphate (AMP) to adenosine. It is a key regulator of purinergic signaling and plays a critical role in modulating immune responses, inflammation, and tissue regeneration 1.","id":38483,"price":470,"purchasable":true,"regular_price":470,"short_description":"CD73, also known as ecto-5'- nucleotidase (NT5E), is a 70 kDa glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme that catalyzes the dephosphorylation of extracellular adenosine monophosphate (AMP) to adenosine. It is a key regulator of purinergic signaling and plays a critical role in modulating immune responses, inflammation, and tissue regeneration 1 .","sku":"","status":"publish","slug":"anti-human-cd73-ad2","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-12-15T08:35:08Z","title":"Anti-Human CD73 (AD-2)","link":"https:\/\/immunostep.com\/product\/anti-human-cd73-ad2\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"IgM is the first antibody produced in a primary immune response and circulates mainly as a high-avidity pentamer. It efficiently activates the classical complement pathway and is also expressed on na\u00efve B cells as part of the B-cell receptor. Anti-human IgM monoclonal antibodies specifically recognize the \u03bc heavy chain and are widely used in flow cytometry and immunofluorescence to identify IgM+ B cells in studies of B-cell maturation, immune function, and related disorders.","id":38344,"price":175,"purchasable":true,"regular_price":175,"short_description":"Immunoglobulin (Ig) G (IgG) is the predominant of five classes of Ig (IgG, IgA, IgM, IgE, and IgD). Igs differ in heavy chain structure and effector function. In normal adults, IgG3 represents~4% of serum IgG. IgG3 activates complement more readily than other IgG subclasses, has high affinity for Fc receptors on agocytes (Fc\u03b3R), crosses the placenta less readily than IgG1 and IgG4 but more so than IgG2, and has an overall half-life of~7 days. Some adults with frequent or severe\u00a0 respiratory tract infection have subnormal IgG3 (<2 SD below respective means) (1-2) Immunoglobulin M (IgM) represents the primary antibody produced during an initial immune response. Structurally, IgM is a pentameric molecule composed of five immunoglobulin units linked by a joining (J) chain, providing it with high avidity for antigens. Owing to its multivalent structure, IgM is highly efficient in activating the classical complement pathway and in promoting agglutination and neutralization of pathogens. In healthy individuals, IgM accounts for approximately 5\u201310% of total serum immunoglobulins and is predominantly expressed on the surface of na\u00efve B lymphocytes as a membrane-bound form (mIgM), where it functions as part of the B-cell receptor (BCR) complex. Upon antigen encounter, IgM plays a key role in the initiation of humoral immune responses and the activation of downstream signaling pathways leading to B-cell\u00a0 differentiation and antibody production. The anti-human IgM monoclonal antibody specifically recognizes the \u03bc heavy chain of human IgM and does not cross-react with other immunoglobulin isotypes (IgG, IgA, IgE, or IgD). When used in flow cytometry or immunofluorescence assays, it enables the identification and quantification of IgM-expressing B cells, facilitating studies of B-cell maturation, immune competence, and abnormal immunoglobulin expression associated with immunodeficiencies, autoimmune diseases, and B-cell malignancies.","sku":"IGMPP5.5-25T","status":"publish","slug":"anti-human-igm-sag3","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/Antibodies_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-11-17T15:30:33Z","title":"Anti-Human IgM (MHM-88)","link":"https:\/\/immunostep.com\/product\/anti-human-igm-sag3\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Solutions"],"description":"CSF tubes incorporate K2EDTA (5.4 mg) as hematological anticoagulant together with a stabilizing agent. The CSF is used for stabilization of cerebrospinal fluid samples for transport and processing in the clinical laboratory in the area of routine Immunohaematological by flow cytometry.","id":38213,"price":110,"purchasable":true,"regular_price":110,"short_description":"CSF tubes incorporate K2EDTA (5.4 mg) as hematological anticoagulant together with a stabilizing agent. The CSF is used for stabilization of cerebrospinal fluid samples for transport and processing in the clinical laboratory in the area of routine Immunohaematological by flow cytometry.","sku":"213361","status":"publish","slug":"csf-tubes","stock_quantity":null,"tags":[],"type":"variable","stock_status":"instock","df_variants_information":["size"],"df_indexable":"auto","category_merchandising":["solutions"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2026\/01\/CSF-TUBES-300x200.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2026\/01\/CSF-TUBES-300x200.jpg","https:\/\/immunostep.com\/wp-content\/uploads\/2025\/11\/CSF-TUBES-2-300x200.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-11-07T11:07:07Z","title":"CSF Tubes","link":"https:\/\/immunostep.com\/product\/csf-tubes\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Kits"],"description":"The intended use of this kit is for the calibration of the standard curve of the HemoStep kit. Calibration ensures the proper performance of the kit and prevents small variations that may occur in the flow cytometer over time affecting the results. The kit consist of a set of microspheres or beads coated with different haemoglobin (Hb) concentrations corresponding to the top and bottom of the standard curve as well as an anti Hb antibody conjugated with phycoerythrin (PE). This combination allows to user to obtain as fluorescen signal value. via flow cytometry analysis and use this fluorescence value tu recalibrate the standard curve if necessary, thus avoiding the need to build a new standard curve, saving time and reagents.","id":38058,"price":0,"purchasable":true,"regular_price":0,"short_description":"This kit is used to calibrate the standard curve of HemoStep, ensuring optimal performance and correcting variations in the flow cytometer. It contains microspheres with different hemoglobin concentrations and an anti-Hb antibody conjugated with PE, allowing fluorescent signals to be obtained for recalibrating the curve without the need to generate a new one, saving time and reagents.","sku":"IMS1511","status":"publish","slug":"calibration-kit-hemostep","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["kits"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/APC-C750_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/APC-C750_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-10-03T15:27:37Z","title":"Calibration kit HemoStep","link":"https:\/\/immunostep.com\/product\/calibration-kit-hemostep\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Lyophilized Exosomes"],"description":"Exosomes are small extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment, the multivesicular body (MVB) 1 , with the plasma membrane. They are thought to provide a means of intercellular communication (2,3) and of transmission of macromolecules between cells allowing the spread of proteins, lipids, mRNA, miRNA and DNA and as contributing factors in the development of several diseases. Exosomes can also modulate cancer microenvironment (4) and the immune response (5,6) .Fluorescent exosomes are labelled by expressing a specific exosome membrane marker (such as CD63) fused to a fluorescent protein (i.e. EGFP) in 293F cells.","id":37930,"price":195,"purchasable":true,"regular_price":195,"short_description":"Exosomes are small extracellular vesicles released when multivesicular bodies fuse with the plasma membrane. They mediate intercellular communication by transferring proteins, lipids, mRNA, miRNA, and DNA, and can influence disease progression, the cancer microenvironment, and immune responses. Fluorescent exosomes can be generated by expressing a membrane marker like CD63 fused to a fluorescent protein (e.g., EGFP) in 293F cells.","sku":"FluoExo","status":"publish","slug":"lyophilized-fluorescent-exosomes","stock_quantity":null,"tags":[],"type":"variable","stock_status":"instock","df_variants_information":["conjugated"],"df_indexable":"auto","category_merchandising":["lyophilized-exosomes"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/09\/DSC_1144-300x200.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2025\/09\/DSC_1144-300x200.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-09-18T11:11:10Z","title":"Lyophilized Fluorescent Exosomes","link":"https:\/\/immunostep.com\/product\/lyophilized-fluorescent-exosomes\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"The antibody recognises CD2, a protein on the surface of T cells and some NK cells, which facilitates T cell adhesion and activation by interacting with CD58. CD2 is key in the immune response, and antibodies such as RPA-2.10 block associated immune functions. Disruption of CD2 is linked to immune disorders and certain cancers.","id":35801,"price":541,"purchasable":true,"regular_price":541,"short_description":"The antibody recognises CD2, a protein on the surface of T cells and some NK cells, which facilitates T cell adhesion and activation by interacting with CD58. CD2 is key in the immune response, and antibodies such as RPA-2.10 block associated immune functions. Disruption of CD2 is linked to immune disorders and certain cancers.","sku":"2SBUV4452-100T","status":"publish","slug":"cd2-rpa-2-10","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PerCP-Cyanine5.5_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PerCP-Cyanine5.5_RUO-IMMUNOSTEP-300x199.jpg","https:\/\/immunostep.com\/wp-content\/uploads\/2025\/11\/CD2-StarBright\u2122-300x278.png"],"availability":"in stock","purchase_price":null,"creation_date":"2025-07-01T10:25:08Z","title":"CD2 (RPA-2.10)","link":"https:\/\/immunostep.com\/product\/cd2-rpa-2-10\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"The monoclonal antibody NP4D6 specifically binds to CD203c (ENPP3), a type II transmembrane glycoprotein with enzymatic activity. CD203c is expressed on basophils and mast cells, and is markedly increased on activated basophils following allergen or IgE stimulation, making it a reliable marker of basophil activation in type I allergies. Its expression has also been observed in neoplastic cells in systemic mastocytosis, secretory endometrial glands and glioma cells. Flow cytometry with the NP4D6 clone is widely used in the diagnosis and monitoring of allergies, mast cell disorders and immunophenotyping studies.","id":35147,"price":565,"purchasable":true,"regular_price":565,"short_description":"NP4D6 detects CD203c (ENPP3), a transmembrane enzyme present on basophils and mast cells that is upregulated upon allergic stimulation, serving as a reliable marker of basophil activation in type I allergies. In addition, CD203c is expressed on neoplastic mast cells, secretory endometrial glands and glioma cells, and is used by flow cytometry in the diagnosis and monitoring of allergic disorders and immunophenotyping.","sku":"203CPE2-100T","status":"publish","slug":"cd203c","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2024\/01\/PE_RUO-IMMUNOSTEP-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-06-18T10:41:30Z","title":"CD203c","link":"https:\/\/immunostep.com\/product\/cd203c\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"The monoclonal antibody Anti-HLA-B27 is directed against the HLA-B27 antigen, a class I surface molecule encoded by the B locus of the human Major Histocompatibility Complex (MHC). This antigen plays a key role in the presentation of microbial peptides to T cells, contributing to immune recognition and response 1. HLA-B27 is expressed in approximately 7% of the Caucasian population, while a related antigen, HLA-B7, is found in about 22%2. The detection of HLA-B27 is clinically significant due to its strong association with inflammatory diseases, particularly ankylosing spondylitis. Over 90% of individuals diagnosed with ankylosing spondylitis express the HLA-B27 antigen, compared to only 7% of asymptomatic individuals3. This monoclonal antibody enables the identification of HLA-B27 specificity within the class I HLA allotype, supporting the diagnosis and monitoring of spondyloarthropathies. Flow cytometry using CYT HLAIB27F provides a rapid and reliable method for assessing HLA-B27 expression in clinical samples 3. Furthermore, structural and functional studies have shown that HLA-B27 may contribute to disease pathogenesis through mechanisms involving misfolding, aberrant immune responses, and interactions with innate immune receptors.","id":34754,"price":520,"purchasable":true,"regular_price":520,"short_description":"The monoclonal antibody Anti-HLA-B27 targets the HLA-B27 antigen, a class I MHC molecule essential for presenting microbial peptides to T cells. HLA-B27 is present in about 7% of Caucasians and is strongly associated with inflammatory disorders, especially ankylosing spondylitis\u2014over 90% of patients with this condition express HLA-B27. Detection of this antigen, particularly via flow cytometry using CYT HLAIB27F, is crucial for diagnosing and monitoring spondyloarthropathies. Additionally, HLA-B27\u2019s role in disease pathogenesis may involve protein misfolding, immune dysregulation, and interactions with innate immunity.","sku":"HLAB27F-100T","status":"publish","slug":"anti-human-hla-b27-hla-abc-m3","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/08\/HLA-B271-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2025\/08\/HLA-B271-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-06-05T15:40:50Z","title":"Anti- Human HLA-B27 (HLA-ABC-m3)","link":"https:\/\/immunostep.com\/product\/anti-human-hla-b27-hla-abc-m3\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Single Antibodies"],"description":"The monoclonal antibody BB7.1 is directed against the HLA-B7 antigen, a polymorphic surface protein of the human MHC class I family. HLA-B7 is expressed on all nucleated cells and forms a heterodimer composed of a specific transmembrane HLA-B heavy chain and a non-covalently associated beta-2 microglobulin light chain 1. MHC class I molecules, including HLA-B7, play a central role in adaptive immunity by presenting intracellularly derived peptides to CD8\u207a T cells. These peptides may originate from endogenous proteins or, through cross-presentation, from extracellular sources. The primary ligands for MHC class I molecules are the T cell receptor (TCR) and the co-receptor CD8, which together mediate antigen-specific immune responses 1. HLA-B7 is one of the most studied alleles within the HLA-B locus, and hundreds of polymorphic variants have been identified. Typing for these alleles is routinely performed in the context of organ and hematopoietic stem cell transplantation to ensure compatibility and reduce the risk of graft rejection 1. In addition to its role in transplantation and immune surveillance, HLA-B7 is increasingly relevant in the field of immunopeptidomics. Antibodies targeting MHC class I molecules, such as BB7.1, are used to isolate peptide-MHC complexes for analysis by high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS\/MS). This approach enables the identification of tumor-specific neoantigens and viral epitopes, contributing to the development of personalized immunotherapies 2.","id":34753,"price":280,"purchasable":true,"regular_price":280,"short_description":"The monoclonal antibody BB7.1 targets HLA-B7, a polymorphic MHC class I antigen expressed on all nucleated cells. HLA-B7 presents intracellular peptides to CD8\u207a T cells, playing a key role in adaptive immunity. It is one of the most studied HLA-B alleles, with significant relevance in transplantation due to its polymorphism and importance in donor-recipient compatibility. Beyond transplantation, BB7.1 is widely used in immunopeptidomics to isolate peptide-MHC complexes for LC-MS\/MS analysis, aiding in the identification of tumor neoantigens and viral epitopes for personalized immunotherapy development.","sku":"HLAB7PE-100T","status":"publish","slug":"anti-human-hla-b7-bb7-1-2","stock_quantity":null,"tags":[],"type":"simple","stock_status":"instock","df_indexable":"auto","category_merchandising":["single-antibodies"],"image_link":"https:\/\/immunostep.com\/wp-content\/uploads\/2025\/08\/HLA-B71-300x199.jpg","images_links":["https:\/\/immunostep.com\/wp-content\/uploads\/2025\/08\/HLA-B71-300x199.jpg"],"availability":"in stock","purchase_price":null,"creation_date":"2025-06-05T15:28:22Z","title":"Anti- Human HLA-B7 (BB7.1)","link":"https:\/\/immunostep.com\/product\/anti-human-hla-b7-bb7-1-2\/"},{"average_rating":"0.00","catalog_visibility":"visible","categories":["Multicolor cocktails"],"description":"The monoclonal antibodies included in this reagent are directed against the HLA-B27 and HLA-B7 antigens, both of which are polymorphic surface proteins belonging to the human MHC class I family. These molecules are expressed on all nucleated cells and consist of a specific transmembrane alpha chain non-covalently associated with beta-2 microglobulin 1. HLA-B27 plays a central role in antigen presentation to CD8\u207a T cells, particularly in the context of intracellular pathogens. It is strongly associated with spondyloarthropathies, especially ankylosing spondylitis, where over 90% of affected individuals express this antigen, compared to only 7% in the general population2. Its expression is routinely assessed in clinical immunology to support diagnosis and disease monitoring. HLA-B7, another classical MHC class I molecule, also presents endogenous peptides to cytotoxic T cells and is involved in immune surveillance. It is one of the most frequently expressed HLA-B alleles in the Caucasian population and is commonly included in HLA typing panels for transplantation compatibility 3. Both antigens are relevant in the field of immunopeptidomics, where antibodies targeting MHC class I molecules are used to isolate peptide-MHC complexes for mass spectrometry analysis. This approach enables the identification of tumor-associated or pathogen-derived peptides, contributing to the development of personalized immunotherapies3.","id":34752,"price":518,"purchasable":true,"regular_price":518,"short_description":"This reagent contains monoclonal antibodies targeting HLA-B27 and HLA-B7, polymorphic MHC class I surface proteins expressed on all nucleated cells. HLA-B27 is notably associated with spondyloarthropathies, particularly ankylosing spondylitis, and is key in antigen presentation to CD8\u207a T cells. HLA-B7, one of the most common alleles in the Caucasian population, also plays a role in immune surveillance and transplantation compatibility. 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